Hamilton E J, Berg H M, Easton C J, Bakker A J
Physiology, School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, Nedlands, Australia.
Amino Acids. 2006 Oct;31(3):273-8. doi: 10.1007/s00726-006-0291-4. Epub 2006 Apr 4.
Taurine increases force production in skeletal muscle, and taurine levels may fall during exercise. The contractile properties and fatigability of extensor digitorum longus (EDL) muscles depleted of taurine by guanodinoethane sulfonate (GES) treatment were investigated. GES treatment decreased muscle taurine levels to <40% of controls. Peak twitch force levels were 23% of controls in GES treated EDL muscles (p < 0.05), but maximal specific force was unaffected. The force-frequency relationship was examined and significantly less force was produced by the GES treated muscles compared to controls at stimulation frequencies from 50 to 100 Hz (p < 0.05). GES treated EDL muscles exhibited significantly slower rates of fatigue than controls (p < 0.05). In skinned fibres, 20 mM GES had a small but significant effect on force production, indicating that GES may have some minor taurine-like effects. In this study, a fall in taurine levels decreased force output, and increased the endurance of EDL skeletal muscles.
牛磺酸可增强骨骼肌的力量生成，且运动过程中牛磺酸水平可能会下降。本研究调查了用胍基乙烷磺酸盐（GES）处理后牛磺酸耗竭的趾长伸肌（EDL）的收缩特性和疲劳性。GES处理使肌肉牛磺酸水平降至对照组的<40%。GES处理的EDL肌肉的峰值抽搐力水平为对照组的23%（p<0.05），但最大比力未受影响。研究了力-频率关系，在50至100Hz的刺激频率下，与对照组相比，GES处理的肌肉产生的力明显更小（p<0.05）。GES处理的EDL肌肉表现出比对照组明显更慢的疲劳速率（p<0.05）。在去膜纤维中，20mM GES对力量生成有微小但显著的影响，表明GES可能有一些轻微的类似牛磺酸的作用。在本研究中，牛磺酸水平的下降降低了力量输出，并增加了EDL骨骼肌的耐力。
