Sowapat Kullathida, Soontrapa Sukree, Sakondhavat Chuanchom
Department of Obstetrics and Gynecology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
J Med Assoc Thai. 2006 Jan;89(1):20-4.
To compare the effectiveness between savlon solution was douching and povidone-iodine solution painting for reducing febrile morbidity after total abdominal hysterectomy.
Clinical trial.
One hundred and fifty patients at Srinagarind Hospital were scheduled for total abdominal hysterectomy (TAH). All subjects were non-randomly allocated to receive either savlon (1:1000 solutions) douching or povidone-iodine (1% solution) painting as pre-operative vaginal preparations. They also received Cefazolin 1 gm. intravenously before the operation. The principal outcome of the study was febrile morbidity.
The overall rate of febrile morbidity was 21 percent. The incidence of febrile morbidity in the savlon vs. povidone-iodine groups was 16 (12/75) and 25 (19/75) percent, respectively. No statistically significant difference was found between the two groups (p-value = 0.16). The odds ratio was 1.78 (95%CI 0.79 to 3.99) and adjusted odds ratio was 2.09(95%CI 0.86 to 5.10) CONCLUSION: The effectiveness between savlon solution douching and povidone-iodine solution painting in conjunction with a prophylactic antibiotic before TAH for reducing febrile morbidity was not significant different.
比较使用Savlon溶液冲洗和聚维酮碘溶液涂抹在降低全腹子宫切除术后发热发病率方面的效果。
临床试验。
宋卡王子大学素林医院的150例患者计划接受全腹子宫切除术（TAH）。所有受试者非随机分配，分别接受Savlon（1:1000溶液）冲洗或聚维酮碘（1%溶液）涂抹作为术前阴道准备。她们在手术前还静脉注射1克头孢唑林。该研究的主要结果是发热发病率。
发热发病率的总体发生率为21%。Savlon组与聚维酮碘组的发热发病率分别为16%（12/75）和25%（19/75）。两组之间未发现统计学上的显著差异（p值 = 0.16）。优势比为1.78（95%置信区间0.79至3.99），调整后的优势比为2.09（95%置信区间0.86至5.10）。结论：在TAH前，Savlon溶液冲洗和聚维酮碘溶液涂抹联合预防性抗生素在降低发热发病率方面的效果无显著差异。
