Burneo Jorge G, Hamilton Margaret, Vezina William, Parrent Andrew
Epilepsy Programme, University of Western Ontario, London, Canada.
Can J Neurol Sci. 2006 Feb;33(1):107-10. doi: 10.1017/s0317167100004807.
Rasmussen's encephalitis is a progressive disease characterized by severe progressive neurological and cognitive deficits. It is a difficult condition to treat with conventional medical treatment and requires, in most of the cases, surgical intervention.
We present the case of a patient with Rasmussen's encephalitis who presented with epilepsia partialis continua, who did not respond to antiepileptic treatment and was evaluated for possible surgical intervention.
The electroencephalographic studies revealed bihemispheric involvement during seizures, although magnetic resonance imaging (MRI) showed a marked right hemispheric atrophy. Hyperperfusion over the right hemisphere was seen with the performance of ictal single photon emission computed tomography (SPECT), which finally guided a right functional hemispherectomy and subsequent seizure control.
Ictal SPECT could be a useful tool in the armamentarium of tools used for the localization of the epileptogenic focus in patients with Rasmussen's encephalitis and other localization-related epilepsies.
拉斯穆森脑炎是一种进行性疾病，其特征为严重的进行性神经和认知缺陷。这是一种用传统医学治疗难以处理的病症，在大多数情况下需要手术干预。
我们报告一例患有拉斯穆森脑炎的患者，该患者表现为持续性部分性癫痫，对抗癫痫治疗无反应，并接受了可能的手术干预评估。
脑电图研究显示发作期间双侧大脑半球均受累，尽管磁共振成像（MRI）显示右侧大脑半球明显萎缩。发作期单光子发射计算机断层扫描（SPECT）显示右侧半球血流灌注增加，最终指导了右侧功能性大脑半球切除术并随后控制了癫痫发作。
发作期SPECT可能是用于拉斯穆森脑炎及其他与定位相关癫痫患者癫痫病灶定位的工具库中的一种有用工具。
