Jiang Yan, Wu Zhijian, You Laijiang, Xiang Hong
College of Materials Science and Engineering, Huaqiao University, Quanzhou 362021, PR China.
Colloids Surf B Biointerfaces. 2006 Apr 15;49(1):55-9. doi: 10.1016/j.colsurfb.2006.02.012. Epub 2006 Apr 3.
The controlled release of sodium salicylate (SS) from the gels derived from bis(trimethoxysilylpropyl)amine (TSPA) or the mixture of TSPA with tetraethoxysilane (TEOS) was investigated. The experimental results suggest that the release of SS can be easily controlled by adjusting the ratio between TSPA and TEOS. Increasing the ratio between TSPA and TEOS lowers the surface area and pore volume of the gels, while enhances the interactions between the drug and the gel matrix. Therefore, reduces the release rate of the drug effectively. The overall release process is found to be diffusion controlled, and the release behavior can be well explained by considering the effects of the textual properties of the gels and the interactions between the drug and the gel matrix. TSPA is found to be a very convenient and effective precursor for the preparation of gels for controlled release of both hydrophilic and hydrophobic drugs, especially water-soluble drugs of small molecules.
研究了水杨酸钠（SS）从双（三甲氧基硅丙基）胺（TSPA）或TSPA与四乙氧基硅烷（TEOS）混合物衍生的凝胶中的控释情况。实验结果表明，通过调节TSPA与TEOS之间的比例可以轻松控制SS的释放。增加TSPA与TEOS之间的比例会降低凝胶的表面积和孔体积，同时增强药物与凝胶基质之间的相互作用。因此，有效地降低了药物的释放速率。发现整体释放过程受扩散控制，并且通过考虑凝胶的结构性质以及药物与凝胶基质之间的相互作用的影响，可以很好地解释释放行为。发现TSPA是制备用于亲水性和疏水性药物尤其是小分子水溶性药物控释的凝胶的非常方便且有效的前体。
