Hayes Finbarr, Barillà Daniela
Faculty of Life Sciences and Manchester Interdisciplinary Biocentre, University of Manchester, 131 Princess Street, Manchester M1 7ND, UK.
Trends Biochem Sci. 2006 May;31(5):247-50. doi: 10.1016/j.tibs.2006.03.002. Epub 2006 Apr 11.
Genome segregation in prokaryotes is a highly ordered process that integrates with DNA replication, cytokinesis and other fundamental facets of the bacterial cell cycle. The segrosome is the nucleoprotein complex that mediates DNA segregation in bacteria, its assembly and organization is best understood for plasmid partition. The recent elucidation of structures of the ParB plasmid segregation protein bound to centromeric DNA, and of the tertiary structures of other segregation proteins, are key milestones in the path to deciphering the molecular basis of bacterial DNA segregation.
原核生物中的基因组分离是一个高度有序的过程，它与DNA复制、胞质分裂以及细菌细胞周期的其他基本方面相互整合。隔离体是介导细菌中DNA分离的核蛋白复合体，其组装和组织在质粒分配方面得到了最好的理解。最近对与着丝粒DNA结合的ParB质粒分离蛋白的结构以及其他分离蛋白的三级结构的阐明，是在破解细菌DNA分离分子基础道路上的关键里程碑。
