糖皮质激素对外毛细胞缺血再灌注损伤的保护作用。
Protective effects of glucocorticoids on ischemia-reperfusion injury of outer hair cells.
作者信息
Tabuchi Keiji, Oikawa Keiko, Murashita Hidekazu, Hoshino Tomofumi, Tsuji Shigeki, Hara Akira
机构信息
Department of Otolaryngology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan.
出版信息
Laryngoscope. 2006 Apr;116(4):627-9. doi: 10.1097/01.mlg.0000200963.69342.d7.
OBJECTIVE
This animal study aimed to investigate effects of glucocorticoids on the functional recovery of outer hair cells (OHCs) after transient ischemia.
METHODS
Distortion-product otoacoustic emission (DPOAE) was examined before, during, and after transient cochlear ischemia of 30 minutes using albino guinea pigs.
RESULTS
DPOAE decreased to noise level during ischemia. On recirculation, DPOAE initially recovered with time until 20 minutes after the onset of reperfusion, but thereafter, the DPOAE level gradually decreased toward the noise level in the control animals. Prednisolone and methylprednisolone significantly improved the DPOAE level 60 minutes after the onset of reperfusion.
CONCLUSIONS
The present findings suggest that glucocorticoids possess protective effects against ischemia-reperfusion injury of OHCs.
目的
本动物研究旨在探讨糖皮质激素对短暂缺血后外毛细胞（OHC）功能恢复的影响。
方法
使用白化豚鼠，在30分钟的短暂耳蜗缺血期间及之后，检测畸变产物耳声发射（DPOAE）。
结果
缺血期间DPOAE降至噪声水平。再灌注时，DPOAE最初随时间恢复，直至再灌注开始后20分钟，但此后，DPOAE水平逐渐降至对照动物的噪声水平。泼尼松龙和甲泼尼龙显著提高了再灌注开始后60分钟的DPOAE水平。
结论
目前的研究结果表明，糖皮质激素对外毛细胞缺血-再灌注损伤具有保护作用。
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