Gutmann David H, Hunter-Schaedle Kim, Shannon Kevin M
Department of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
J Clin Invest. 2006 Apr;116(4):847-52. doi: 10.1172/JCI28271.
The urgent need for better cancer treatments has stimulated interest in employing small-animal models to evaluate potential drug therapies. Robust mouse models of many human cancers have been generated using sophisticated technologies for engineering germ-line mutations. As we enter into an age of targeted therapeutics, these strains provide novel platforms for validating new anticancer drugs, assessing therapeutic index, identifying surrogate markers of tumor progression, and defining epigenetic and environmental influences on tumorigenesis.
对更好的癌症治疗方法的迫切需求激发了人们利用小动物模型评估潜在药物疗法的兴趣。利用复杂的技术对种系突变进行工程改造,已经建立了许多人类癌症的强健小鼠模型。随着我们进入靶向治疗时代,这些品系为验证新的抗癌药物、评估治疗指数、识别肿瘤进展的替代标志物以及确定表观遗传和环境对肿瘤发生的影响提供了新的平台。