Carlier Michèle, Stefanini Silvia, Deruelle Christine, Volterra Virginia, Doyen Anne-Lise, Lamard Christine, de Portzamparc Véronique, Vicari Stefano, Fisch Gene
Centre de Recherche PsyCLE, UFR PSE, Université de Provence, Aix en Provence, France.
Behav Genet. 2006 May;36(3):365-76. doi: 10.1007/s10519-006-9048-9. Epub 2006 Apr 4.
Persons with trisomy 21 (T21) and Williams-Beuren syndrome (WBS) have different brain abnormalities which may affect manual laterality. We assessed 45 persons with T21 and 34 with WBS (mean age 13) and 81 typically developing children (TD). Manual laterality was assessed with a fifteen-item task administered two times, and Bishop's card-reaching task. We found more left-handers in the T21 group compared to the other two groups. Inconsistent laterality was higher in the two groups with genetic diseases than in the TD group. For Bishop's test, both T21 and WBS participants were less right-oriented than the TD group. They displayed different response patterns in midline crossing when reaching for the cards, but did not display more midline crossing inhibition than the TD group. Is atypical handedness linked to specific genetic syndromes and, more specifically for persons with T21, to the trisomy of some of the genes?
患有21三体综合征（T21）和威廉姆斯-博伦综合征（WBS）的人有不同的脑部异常，这可能会影响用手偏好。我们评估了45名T21患者、34名WBS患者（平均年龄13岁）以及81名发育正常的儿童（TD）。用一项包含15个项目的任务进行了两次测试来评估用手偏好，同时还进行了毕晓普取卡任务。我们发现，与其他两组相比，T21组中左利手的人更多。患有遗传疾病的两组的用手偏好不一致程度高于TD组。在毕晓普测试中，T21和WBS参与者的右向性都低于TD组。他们在取卡时越过中线时表现出不同的反应模式，但与TD组相比，并没有表现出更多的中线交叉抑制。非典型用手偏好是否与特定的遗传综合征有关，更具体地说，对于T21患者，是否与某些基因的三体性有关？
