Ets-1原癌蛋白在胃肠道间质瘤、平滑肌瘤和神经鞘瘤中的表达。
Expression of Ets-1 proto-oncoprotein in gastrointestinal stromal tumors, leiomyomas and schwannomas.
作者信息
Nakayama Toshiyuki, Yoshizaki Ayumi, Naito Shinji, Wen Chun-Yang, Alipov Gabit, Yakata Yuichi, Sekine Ichiro
机构信息
Department of Molecular Pathology, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan.
出版信息
World J Gastroenterol. 2006 Mar 21;12(11):1743-6. doi: 10.3748/wjg.v12.i11.1743.
AIM
Gastrointestinal stromal tumors (GISTs) are rare. GISTs differ from other mesenchymal tumors of the gastrointestinal tract (e.g. leiomyomas and schwannomas). The purpose of this study was to investigate the role of Ets-1 in the growth and differentiation of GISTs.
METHODS
Twenty-eight GISTs, nine leiomyomas and six schwannomas were examined by immunohistochemical staining method for Ets-1 in this study. Specimens were selected from surgical pathology archival tissues at Nagasaki University Hospital.
RESULTS
Ets-1 protein was expressed in the cytoplasm of cells in all of these tumors. Immunohistochemical staining revealed that 27 GISTs (96.4%), six leiomyomas (66.7%), and five schwannomas (83.3%) were positive for Ets-1. Ets-1 expression was statistically different between GISTs and leiomyomas (P<0.005). However, there was no correlation between Ets-1 expression and clinical risk categories.
CONCLUSION
Ets-1 plays an important role in the growth and differentiation of GISTs, leiomyomas and schwannomas.
目的
胃肠道间质瘤（GISTs）较为罕见。GISTs与胃肠道的其他间充质肿瘤（如平滑肌瘤和神经鞘瘤）不同。本研究的目的是探讨Ets-1在GISTs生长和分化中的作用。
方法
本研究采用免疫组织化学染色法检测28例GISTs、9例平滑肌瘤和6例神经鞘瘤中的Ets-1。标本取自长崎大学医院手术病理存档组织。
结果
所有这些肿瘤细胞的细胞质中均表达Ets-1蛋白。免疫组织化学染色显示，27例GISTs（96.4%）、6例平滑肌瘤（66.7%）和5例神经鞘瘤（83.3%）的Ets-1呈阳性。GISTs和平滑肌瘤之间的Ets-1表达存在统计学差异（P<0.005）。然而，Ets-1表达与临床风险类别之间无相关性。
结论
Ets-1在GISTs、平滑肌瘤和神经鞘瘤的生长和分化中起重要作用。
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