Michaluk J, Antkiewicz-Michaluk L, Rokosz-Pelc A, Vetulani J
Department of Biochemistry, Polish Academy of Sciences, Krakow.
Pol J Pharmacol Pharm. 1991 Mar-Apr;43(2):115-9.
Two subpopulations of Albino Swiss mice were selected on the basis of their response to a dose of 20 mg/kg ip of morphine: individuals in which the drug constantly produced sedation, and those which responded with running fit. Both subpopulations of mice had cerebral opiate delta and mu receptors (defined as [3H]DADLE and [3H]naloxone binding sites) of similar Bmax and KD values but mice responding with sedation showed lower density of alpha 1-adrenoceptors (defined as [3H]prazosin binding sites) as compared both with mice reacting with running fit or randomly selected animals. Chronic administration of imipramine resulted in a significant increase in the density of [3H]prazosin binding sites in the mice responding with sedation, but not in the animals responding with running fit.
基于对白化瑞士小鼠腹腔注射20毫克/千克吗啡剂量的反应，选择了两个亚群：药物持续产生镇静作用的个体，以及表现出奔跑发作反应的个体。这两个亚群的小鼠都具有脑阿片δ和μ受体（定义为[3H]DADLE和[3H]纳洛酮结合位点），其Bmax和KD值相似，但表现出镇静作用的小鼠与表现出奔跑发作反应的小鼠或随机选择的动物相比，α1 - 肾上腺素能受体（定义为[3H]哌唑嗪结合位点）的密度较低。慢性给予丙咪嗪导致表现出镇静作用的小鼠中[3H]哌唑嗪结合位点的密度显著增加，但对表现出奔跑发作反应的动物没有影响。
