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慢性电惊厥治疗可对抗吗啡戒断引起的皮质β-肾上腺素能受体上调。

Chronic electroconvulsive treatment counteracts cortical beta-adrenoceptor upregulation induced by morphine abstinence.

作者信息

Vetulani J, Antkiewicz-Michaluk L, Michaluk J, Rokosz-Pelc A

机构信息

Department of Biochemistry, Polish Academy of Sciences, Kraków.

出版信息

Pol J Pharmacol Pharm. 1991 Mar-Apr;43(2):89-93.

PMID:1658759
Abstract

Morphine treatment (20 mg/kg for 7 consecutive days) did not affect the density of [3H]dihydroalprenolol ([3H]DHA) binding sites in the cortical membranes of the rat, but during naloxone-precipitated abstinence syndrome the density of these sites increased. Electroconvulsive treatment for 6 days, which by itself decreased the density of [3H]DHA binding sites, prevented the increase.

摘要

吗啡治疗（连续7天给予20毫克/千克）并未影响大鼠皮质膜中[3H]二氢阿普洛尔（[3H]DHA）结合位点的密度，但在纳洛酮诱发的戒断综合征期间，这些位点的密度增加。为期6天的电惊厥治疗本身会降低[3H]DHA结合位点的密度，可阻止这种增加。

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