[Effect of corticoliberin and naloxone on the functional activity of the hypophyseal-gonadal system in monkeys].

Experiments were staged on male Papio hamadryas for a study of CRF and naloxone action on the time course of LH and testosterone in peripheral blood. LH was determined by a biological micromethod in vitro; ACTH, cortisol and testosterone were determined by radioimmunoassays. Exogenous CRF was shown to increase inhibitory action of acute "procedure" stress (frequent fixation of monkeys and venipuncture for taking blood samples) of the secretion of LH but not testosterone. Opioid preceptor blockade with naloxone prevented the appearance of inhibitory action of stress and CRF on hypophyseal gonadotropic function rather than on testicular secretory activity. The time course of LH and testosterone after naloxone administration of naloxone combined with CRF has shown that inhibition of testosterone secretion in stress does not depend on a response of gonadotropins and is determined by other (additional) factors.