小鼠视黄酸受体α2亚型由一个含有视黄酸反应元件的启动子转录而来。
Mouse retinoic acid receptor alpha 2 isoform is transcribed from a promoter that contains a retinoic acid response element.
作者信息
Leroy P, Nakshatri H, Chambon P
机构信息
Laboratoire de Génétique Moléculaire des Eucaryotes, Unité 184 de Biologie Moléculaire et de Génie Génétique, Institut National de la Santé et de la Recherche Médicale, Strasbourg, France.
出版信息
Proc Natl Acad Sci U S A. 1991 Nov 15;88(22):10138-42. doi: 10.1073/pnas.88.22.10138.
We have characterized the promoter of the mouse retinoic acid receptor alpha 2 (mRAR-alpha 2) isoform. This promoter contains a retinoic acid response element (RARE) that closely resembles the RARE that is present in the RAR-beta 2 promoter. Moreover, RAR-alpha 2 and RAR-beta 2 proximal promoter sequences are similar to each other and generate transcripts whose respective start sites are located at similar positions. The RAR-alpha 2 RARE consists of two directly repeated 5'-GTTCA-3' motifs to which all three RARs (alpha, beta, and gamma) bind in vitro.
我们已对小鼠视黄酸受体α2（mRAR-α2）亚型的启动子进行了表征。该启动子包含一个视黄酸反应元件（RARE），它与RAR-β2启动子中存在的RARE非常相似。此外，RAR-α2和RAR-β2近端启动子序列彼此相似，并产生各自起始位点位于相似位置的转录本。RAR-α2 RARE由两个直接重复的5'-GTTCA-3'基序组成，所有三种RAR（α、β和γ）在体外均能与之结合。
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