Fuller F B
California Institute of Technology, Sloan 253-37, Pasadena, California 91125.
Proc Natl Acad Sci U S A. 1978 Aug;75(8):3557-61. doi: 10.1073/pnas.75.8.3557.
A closed duplex DNA molecule relaxed and containing nucleosomes has a different linking number from the same molecule relaxed and without nucleosomes. What does this say about the structure of the nucleosome? A mathematical study of this question is made, representing the DNA molecule by a ribbon. It is shown that the linking number of a closed ribbon can be decomposed into the linking number of a reference ribbon plus a sum of locally determined "linking differences."
一个松弛且含有核小体的闭合双链DNA分子与同一个松弛且不含核小体的分子具有不同的连环数。这对于核小体的结构说明了什么?对这个问题进行了数学研究,用一条带代表DNA分子。结果表明,闭合带的连环数可以分解为参考带的连环数加上一组局部确定的“连环差异”之和。