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[表柔比星-碘油对原发性肝癌的化疗栓塞]

[Chemoembolization of primary liver cancer using epirubicin-lipiodol].

作者信息

Pirschel J, Lauchart W

机构信息

Abteilung für Radiologische Diagnostik, Universität Tübingen.

出版信息

Rofo. 1991 Nov;155(5):409-15. doi: 10.1055/s-2008-1033287.

Abstract

The double supply of the liver allows one to perform specific embolisation of liver carcinomas since these are mostly supplied arterially. According to their occlusion characteristics--central, peripheral, capillary--different embolising materials are suitable for tumour embolisation under varying conditions. Oily substances cause capillary occlusion and can be used in conjunction with chemotherapeutic agents. This study deals with the results from lipiodol-epirubicin embolisation in 25 patients with hepatocarcinomas and cholangiocarcinomas. In a three-and-a-half year follow-up period 16 of these 25 patients died, maximum survival time being 28.4 months. Survival varied from 9.2 to 28.4 months compared with a survival time of 2-8 months in untreated patients. In this case hypervascular tumours have a better prognosis than the rarer hypovascular tumours because of improved deposition and activity of the chemotherapeutic agent.

摘要

肝脏的双重供血使得人们能够对肝癌进行特定的栓塞治疗,因为肝癌大多由动脉供血。根据其阻塞特性——中央型、周边型、毛细血管型——不同的栓塞材料在不同条件下适用于肿瘤栓塞。油性物质会导致毛细血管阻塞,可与化疗药物联合使用。本研究探讨了25例肝癌和胆管癌患者使用碘油-表柔比星栓塞的结果。在三年半的随访期内,这25例患者中有16例死亡,最长生存时间为28.4个月。与未治疗患者2至8个月的生存时间相比,生存时间在9.2至28.4个月之间。在这种情况下,由于化疗药物的沉积和活性提高,富血管肿瘤的预后比罕见的乏血管肿瘤更好。

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