Palmer H M, Young H
Scottish Neisseria gonorrhoeae Reference Laboratory, Laboratory Medicine (Microbiology), Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh EH16 4SA, UK.
Int J STD AIDS. 2006 Apr;17(4):254-6. doi: 10.1258/095646206776253408.
In 2003, episodes of gonorrhoea caused by ciprofloxacin-resistant strains increased to 15.3% from 11% in 2002. This was coincident with a marked increase in strains characterized as serogroup WI, ciprofloxacin-resistant bearing the tetracycline resistance plasmid. Molecular typing of these strains, using Neisseria gonorrhoeae multiantigen sequence typing (NG-MAST) revealed 71% (34/48) were of the same sequence type, ST338, accounting for 4.1% (34/824) of all strains in 2003. Epidemiological data demonstrated that transmission of ST338 was associated with men who have sex with men (MSM; 23/27), acquisition within the UK (22/26) and having two or more partners in the previous three-month period (18/27). The combined use of highly discriminatory typing and epidemiological surveillance helps to identify successful transmission networks.
2003年，由耐环丙沙星菌株引起的淋病发病率从2002年的11%增至15.3%。这与血清群WI（携带四环素耐药质粒的耐环丙沙星菌株）显著增加同时出现。使用淋病奈瑟菌多抗原序列分型（NG-MAST）对这些菌株进行分子分型显示，71%（34/48）为同一序列类型，即ST338，占2003年所有菌株的4.1%（34/824）。流行病学数据表明，ST338的传播与男男性行为者（MSM；23/27）、在英国境内感染（22/26）以及在过去三个月内有两个或更多性伴侣（18/27）有关。高分辨率分型与流行病学监测相结合有助于识别成功的传播网络。
