de Lemos Mário L, Hamata Linda, Vu Thanh
British Columbia Cancer Agency, Vancouver, BC, V5Z 4E6, Canada.
J Oncol Pharm Pract. 2005 Dec;11(4):155-7. doi: 10.1191/1078155205jp164oa.
Etoposide intravenous solution is associated with leaching of diethylhexyl phthalate (DEHP) from bags and tubings made from polyvinyl chloride (PVC). Recent evidence suggests that this may be more substantial than previously found. Since DEHP is potentially hepatotoxic and carcinogenic, it is preferable to prepare and administer etoposide bags and tubings made from non-PVC materials.
依托泊苷静脉溶液与邻苯二甲酸二（2-乙基己基）酯（DEHP）从聚氯乙烯（PVC）制成的袋子和管道中浸出有关。最近的证据表明，这种浸出可能比以前发现的情况更严重。由于DEHP具有潜在的肝毒性和致癌性，因此最好使用非PVC材料制成的袋子和管道来制备和输注依托泊苷。
