Hardie Donald, Sangster Alan J, Cronin Nigel J
Electrical, Electronic, and Computer Engineering Department, Heriot-Watt University, Riccarton, Edinburgh, UK.
Electromagn Biol Med. 2006;25(1):29-43. doi: 10.1080/15368370600572953.
Microwave tumor ablation (MTA) offers a new approach for the treatment of hepatic neoplastic disease. Reliable and accurate information regarding the heat distribution inside biological tissue subjected to microwave thermal ablation is important for the efficient design of microwave applicators and for optimizing experiments, which aim to assess the effects of therapeutic treatments. Currently there are a variety of computational methods based on different vascular structures in tissue, which aim to model heat distribution during ablation. This paper presents results obtained from two such computational models for temperature distributions produced by a clinical 2.45 GHz MTA applicator immersed in unperfused ex vivo bovine liver, and compares them with measured results from a corresponding ex vivo experiment. The computational methods used to model the temperature distribution in tissue caused by the insertion of a 5.6 mm diameter "wandlike" microwave applicator are the Green's function method and the finite element method (FEM), both of which provide solutions of the heat diffusion partial differential equation. The results obtained from the coupled field simulations are shown to be in good agreement with a simplified analysis based on the bio-heat equation and with ex vivo measurements of the heat distribution produced by the clinical MTA applicator.
微波肿瘤消融（MTA）为肝肿瘤疾病的治疗提供了一种新方法。对于高效设计微波施加器以及优化旨在评估治疗效果的实验而言，有关生物组织在微波热消融作用下内部热分布的可靠且准确的信息非常重要。目前，基于组织中不同血管结构存在多种计算方法，旨在模拟消融过程中的热分布。本文展示了由一个临床用2.45 GHz MTA施加器浸没在未灌注的离体牛肝脏中产生的温度分布的两种此类计算模型所获得的结果，并将它们与相应离体实验的测量结果进行比较。用于模拟插入直径5.6毫米“棒状”微波施加器引起的组织温度分布的计算方法是格林函数法和有限元法（FEM），这两种方法都能提供热扩散偏微分方程的解。耦合场模拟获得的结果与基于生物热方程的简化分析以及临床MTA施加器产生的热分布的离体测量结果显示出良好的一致性。
