Riedel D, Ghate M, Nene M, Paranjape Rs, Mehendale Sm, Bollinger Rc, Sacktor N, McArthur Jc, Nath A
Department of Neurology, Johns Hopkins University, Baltimore, Maryland 21287, USA.
J Neurovirol. 2006 Feb;12(1):34-8. doi: 10.1080/13550280500516500.
Although human immunodeficiency virus (HIV) clade C virus infects the largest populations worldwide, to date there are no prospective studies reported thus far to determine the incidence or prevalence of HIV dementia in this population. HIV clade C virus is a CCR5-tropic virus and thus predominantly infects macrophages, which are the key cells implicated in the pathogenesis of HIV dementia. However, HIV dementia has only rarely been reported in these populations. The authors thus used a recently developed International HIV Dementia Scale (IHDS) to screen a well-characterized cohort of HIV-infected discordant couples in Pune, India. 48 HIV+ subjects with CD4 cell count <200 cells/mm(3) and 48 HIV- subjects were studied. The HIV+ subjects had significantly lower IHDS scores compared to the HIV- subjects. 35% of the HIV+ subjects and 15% of the HIV- subjects scored < 10 on the IHDS. These observations suggest that the prevalence of HIV dementia may be higher in this population than previously reported. More importantly, it demonstrates that the IHDS can be used as a screening tool in the Indian population.
尽管人类免疫缺陷病毒（HIV）C亚型病毒感染了全球最大数量的人群，但迄今为止，尚无前瞻性研究来确定该人群中HIV痴呆症的发病率或患病率。HIV C亚型病毒是一种趋化因子受体5（CCR5）嗜性病毒，因此主要感染巨噬细胞，而巨噬细胞是与HIV痴呆症发病机制相关的关键细胞。然而，在这些人群中，HIV痴呆症的报告却极为罕见。因此，作者使用了最近开发的国际HIV痴呆症量表（IHDS），对印度浦那一组特征明确的HIV感染不一致夫妻进行筛查。研究了48名CD4细胞计数<200个细胞/mm³的HIV阳性受试者和48名HIV阴性受试者。与HIV阴性受试者相比，HIV阳性受试者的IHDS得分显著更低。35%的HIV阳性受试者和15%的HIV阴性受试者在IHDS上的得分<10分。这些观察结果表明，该人群中HIV痴呆症的患病率可能高于先前报告的水平。更重要的是，这表明IHDS可作为印度人群的一种筛查工具。
