Hintzen R Q, van Lier R A, Kuijpers K C, Baars P A, Schaasberg W, Lucas C J, Polman C H
Central Laboratory, The Netherlands Red Cross Blood Transfusion Service, University of Amsterdam.
J Neuroimmunol. 1991 Dec;35(1-3):211-7. doi: 10.1016/0165-5728(91)90175-7.
The expression of the T cell membrane molecule CD27--a molecule that has recently been shown to belong to the nerve growth factor receptor superfamily--is strongly increased after activation of T lymphocytes via the T cell receptor/CD3 complex. In addition, activated cells release a 28-32 kDa soluble form of CD27 in their supernatant which can also be detected in serum and urine of healthy individuals. In this study we show that levels of soluble (s) CD27 are significantly elevated in cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients and of patients and of suffering from other inflammatory neurological diseases (OIND), whereas increased levels of sCD25 (soluble interleukin-2 receptor) were only found in CSF of patients with OIND. In MS patients, a significant correlation was found between CSF sCD27 titer and IgG index.
T细胞膜分子CD27——最近已证明其属于神经生长因子受体超家族的一种分子——在T淋巴细胞通过T细胞受体/CD3复合物激活后表达显著增加。此外，活化细胞在其上清液中释放一种28 - 32 kDa的可溶性CD27形式，在健康个体的血清和尿液中也能检测到。在本研究中，我们发现多发性硬化症（MS）患者以及患有其他炎性神经疾病（OIND）的患者的脑脊液（CSF）中可溶性（s）CD27水平显著升高，而仅在OIND患者的脑脊液中发现可溶性白细胞介素-2受体（sCD25）水平升高。在MS患者中，脑脊液sCD27滴度与IgG指数之间存在显著相关性。
