Znati K, Tadlaoui N, Bernoussi Z, Mikou A, Mahassini N, Jahid A, Mansouri F, Hachimi A
Laboratoire Central d'Anatomie Pathologique, Avicenne, CHU Rabat-Maroc.
Ann Endocrinol (Paris). 2006 Mar;67(1):64-8. doi: 10.1016/s0003-4266(06)72561-6.
Thyroid sarcomatoid carcinoma is a rare and aggressive neoplasm composed of a follicular carcinoma which is contiguous or admixed with a pleomorphic spindle cell component. We report the case of a thyroid tumor reputed to have a poor outcome, in a 62-year-old woman. The radical thyroidectomy specimen was totally invaded. Results of immunoperoxidase staining for thyroglobulin and epithelial markers were positive in the areas of follicular carcinoma and negative in the sarcomatous component. The patient died a few days later due to septic shock. The epithelial and mesenchymal components of thyroid carcinosarcoma were both part of the neoplastic parenchyma and evolved from a single common stem cell, in agreement with the hypothesis that the tumors are of monoclonal origin. The definition of this tumor as its histogenesis and prognostic are discussed.
甲状腺肉瘤样癌是一种罕见的侵袭性肿瘤，由滤泡癌组成，滤泡癌与多形性梭形细胞成分相邻或混合存在。我们报告了一例62岁女性甲状腺肿瘤，该肿瘤预后较差。根治性甲状腺切除标本被完全侵犯。甲状腺球蛋白和上皮标志物免疫过氧化物酶染色结果在滤泡癌区域呈阳性，在肉瘤成分中呈阴性。患者几天后因感染性休克死亡。甲状腺癌肉瘤的上皮和间充质成分均为肿瘤实质的一部分，且起源于单一共同干细胞，这与肿瘤为单克隆起源的假说一致。本文讨论了该肿瘤的组织发生学定义及其预后。
