Lutoslawska G, Niedbalska M, Skierska E, Keska A, Szpocinska-Byszewska E, Zołnowska M
Department of Biochemistry, Academy of Physical Education, Warsaw, Poland.
J Sports Med Phys Fitness. 2006 Mar;46(1):138-42.
Highly active females are at risk of athletic menstrual irregularities including anovulatory menstrual cycles, oligomenorrhea and even amenorrhea. On the other hand, the functional relationship between endocrine pancreas and ovaries is supported by numerous studies indicating that disturbed female sex hormone secretion coexists with insulin resistance and glucose intolerance. However, the relationship between circulating beta islet and ovarian hormones in regularly menstruating active women with ovulatory and anovulatory menstrual cycle has not been studied.
A total of 32 regularly menstruating women participated in the study. Prospective subjects monitored their BBT for 3 months before the study. The determination of plasma progesterone levels between days 5-8 and again between days 19-22 of the menstrual cycles made possible the classification of subjects as ovulating or non-ovulating. Plasma 17-beta-estradiol, testosterone, insulin, proinsulin, C-peptide and glucose concentrations were assayed on the same menstrual cycle days as progesterone.
There were no differences in circulating insulin, C-peptide and glucose between non-ovulating and ovulating women. In contrast, in non-ovulating subjects plasma proinsulin concentrations between days 19-22 were slightly, but significantly higher than between days 5-8 of the menstrual cycle (P<0.05). Exclusively in non-ovulating women significant and positive correlation was noted between circulating proinsulin and 17-beta-estradiol in data collected from both days 5-8 and 19-22 of the menstrual cycle (P<0.008).
Our results indicate that in the face of low circulating progesterone and subsequent anovulation circulating 17-beta-estradiol slightly, but significantly, affect either pancreatic beta-cell biosynthetic activity or proinsulin hepatic and/or renal clearance.
运动活跃的女性有发生运动性月经紊乱的风险，包括无排卵月经周期、月经过少甚至闭经。另一方面，众多研究支持内分泌胰腺与卵巢之间的功能关系，这些研究表明女性性激素分泌紊乱与胰岛素抵抗和葡萄糖不耐受并存。然而，对于月经周期正常、有排卵和无排卵月经周期的活跃女性，循环中的β胰岛激素与卵巢激素之间的关系尚未得到研究。
共有32名月经周期正常的女性参与了这项研究。前瞻性受试者在研究前3个月监测其基础体温。在月经周期的第5 - 8天以及再次在第19 - 22天测定血浆孕酮水平，从而将受试者分为排卵或不排卵。在与孕酮相同的月经周期日测定血浆17-β-雌二醇、睾酮、胰岛素、胰岛素原、C肽和葡萄糖浓度。
不排卵女性和排卵女性在循环胰岛素、C肽和葡萄糖方面没有差异。相比之下，在不排卵受试者中，月经周期第19 - 22天的血浆胰岛素原浓度略高于但显著高于第5 - 8天（P<0.05）。仅在不排卵女性中，在月经周期第5 - 8天和第19 - 22天收集的数据中，循环胰岛素原与17-β-雌二醇之间存在显著正相关（P<0.008）。
我们的结果表明，面对低循环孕酮和随后的无排卵情况，循环中的17-β-雌二醇会轻微但显著地影响胰腺β细胞的生物合成活性或胰岛素原的肝脏和/或肾脏清除率。
