遗传性痉挛性截瘫的中枢运动传导研究
Central motor conduction studies in hereditary spastic paraplegia.
作者信息
Schady W, Dick J P, Sheard A, Crampton S
机构信息
Department of Neurology, Manchester Royal Infirmary, UK.
出版信息
J Neurol Neurosurg Psychiatry. 1991 Sep;54(9):775-9. doi: 10.1136/jnnp.54.9.775.
Abstract
Central motor conduction (CMC) studies were carried out in 25 patients with hereditary spastic paraplegia (HSP). Responses evoked in the lower limbs by transcranial magnetic stimulation of the motor cortex were bilaterally absent in 33% of the patients and, when recordable, were delayed in 75% of cases. Responses in the upper limbs were mostly normal except for those from the five members of one family, which were considerably delayed. There was no correlation between CMC parameters and age, duration of disease or upper limb hyperreflexia. CMC time to the tibialis anterior correlated with disability in patients with juvenile-onset HSP. It is concluded that CMC studies are not useful in detecting subclinical lesions in hereditary spastic paraplegia but may be of value in identifying subgroups of the disease.
摘要
对25例遗传性痉挛性截瘫（HSP）患者进行了中枢运动传导（CMC）研究。运动皮层经颅磁刺激在下肢诱发的反应在33%的患者中双侧缺失，而在可记录时，75%的病例出现延迟。除了来自一个家族的五名成员的反应明显延迟外，上肢的反应大多正常。CMC参数与年龄、病程或上肢亢进反射之间无相关性。青少年起病的HSP患者中，胫前肌的CMC时间与残疾程度相关。结论是，CMC研究对检测遗传性痉挛性截瘫的亚临床病变无用，但可能对识别该疾病的亚组有价值。
相似文献
1
Central motor conduction studies in hereditary spastic paraplegia.
J Neurol Neurosurg Psychiatry. 1991 Sep;54(9):775-9. doi: 10.1136/jnnp.54.9.775.
2
Central motor conduction in hereditary motor and sensory neuropathy and hereditary spastic paraplegia.
Electromyogr Clin Neurophysiol. 1999 Sep;39(6):331-5.
3
Hereditary "pure" spastic paraplegia: a study of nine families.
J Neurol Neurosurg Psychiatry. 1993 Feb;56(2):175-81. doi: 10.1136/jnnp.56.2.175.
4
Central motor conduction in a family with hereditary motor and sensory neuropathy with pyramidal signs (HMSN V).
J Neurol Neurosurg Psychiatry. 1991 Jun;54(6):511-5. doi: 10.1136/jnnp.54.6.511.
5
Changes in corticospinal facilitation of lower limb spinal motor neurons after spinal cord lesions.
J Neurol Neurosurg Psychiatry. 1992 Jan;55(1):20-4. doi: 10.1136/jnnp.55.1.20.
6
Motor and somatosensory evoked potentials in Autosomal Dominant Hereditary Spastic Paraparesis (ADHSP) linked to chromosome 2p, SPG4.
Brain Res Bull. 2007 Sep 28;74(4):243-9. doi: 10.1016/j.brainresbull.2007.06.018. Epub 2007 Jul 17.
7
[Familial spastic spinal paralysis--clinical spectrum and differential diagnostic considerations].
Fortschr Neurol Psychiatr. 1991 May;59(5):176-82. doi: 10.1055/s-2007-1000692.
8
Magnetic brain stimulation: central motor conduction studies in multiple sclerosis.
Ann Neurol. 1987 Dec;22(6):744-52. doi: 10.1002/ana.410220611.
9
[A case of spastic paraparesis with mental deterioration and markedly thin corpus callosum--callosal dysfunction demonstrated by magnetic stimulation].
Rinsho Shinkeigaku. 1998 May;38(5):418-22.
10
Hereditary motor and sensory neuropathies and hereditary spastic paraplegia: a magnetic stimulation study.
Ann Neurol. 1990 Jul;28(1):43-9. doi: 10.1002/ana.410280109.
引用本文的文献
1
Motor Evoked Potentials in Hereditary Spastic Paraplegia-A Systematic Review.
Front Neurol. 2019 Sep 18;10:967. doi: 10.3389/fneur.2019.00967. eCollection 2019.
2
Superconditioning TMS for examining upper motor neuron function in MND.
Exp Brain Res. 2019 Aug;237(8):2087-2103. doi: 10.1007/s00221-019-05573-4. Epub 2019 Jun 7.
3
Paired Stimulation to Promote Lasting Augmentation of Corticospinal Circuits.
Neural Plast. 2016;2016:7043767. doi: 10.1155/2016/7043767. Epub 2016 Oct 9.
4
Enhanced reticulospinal output in patients with (REEP1) hereditary spastic paraplegia type 31.
J Neurol. 2013 Dec;260(12):3182-4. doi: 10.1007/s00415-013-7178-6. Epub 2013 Nov 13.
5
Electrophysiological characterisation of motor and sensory tracts in patients with hereditary spastic paraplegia (HSP).
Orphanet J Rare Dis. 2013 Oct 9;8:158. doi: 10.1186/1750-1172-8-158.
6
Altered cortical inhibitory function in children with spastic diplegia: a TMS study.
Exp Brain Res. 2008 Apr;186(4):611-8. doi: 10.1007/s00221-007-1267-7. Epub 2008 Jan 23.
7
Motor system abnormalities in hereditary spastic paraparesis type 4 (SPG4) depend on the type of mutation in the spastin gene.
J Neurol Neurosurg Psychiatry. 2003 Aug;74(8):1109-12. doi: 10.1136/jnnp.74.8.1109.
8
Hereditary spastic paraparesis: a review of new developments.
J Neurol Neurosurg Psychiatry. 2000 Aug;69(2):150-60. doi: 10.1136/jnnp.69.2.150.
9
Autosomal dominant pure spastic paraplegia: a clinical, paraclinical, and genetic study.
J Neurol Neurosurg Psychiatry. 1998 Jan;64(1):61-6. doi: 10.1136/jnnp.64.1.61.
10
Hereditary "pure" spastic paraplegia: a study of nine families.
J Neurol Neurosurg Psychiatry. 1993 Feb;56(2):175-81. doi: 10.1136/jnnp.56.2.175.
本文引用的文献
1
Plasma exchange in chronic inflammatory demyelinating polyradiculoneuropathy.
Muscle Nerve. 1985 May;8(4):321-7. doi: 10.1002/mus.880080409.
2
Hereditary (familial) spastic paraplegia; further clinical and pathologic observations.
AMA Arch Neurol Psychiatry. 1956 Feb;75(2):144-62. doi: 10.1001/archneurpsyc.1956.02330200038005.
3
Stimulation of the cerebral cortex in the intact human subject.
Nature. 1980 May 22;285(5762):227. doi: 10.1038/285227a0.
4
Hereditary "pure" spastic paraplegia: a clinical and genetic study of 22 families.
J Neurol Neurosurg Psychiatry. 1981 Oct;44(10):871-83. doi: 10.1136/jnnp.44.10.871.
5
Spinal somatosensory evoked potentials in hereditary spastic paraplegia.
J Neurol Neurosurg Psychiatry. 1981 Mar;44(3):243-6. doi: 10.1136/jnnp.44.3.243.
6
A study of posterior column function in familial spastic paraplegia.
J Neurol Neurosurg Psychiatry. 1982 Jan;45(1):46-9. doi: 10.1136/jnnp.45.1.46.
7
Visual, auditory and somatosensory pathway involvement in hereditary cerebellar ataxia, Friedreich's ataxia and familial spastic paraplegia.
Electroencephalogr Clin Neurophysiol. 1981 Oct;52(4):283-97. doi: 10.1016/0013-4694(81)90057-2.
8
F-wave velocity in the central segment of the median and ulnar nerves. A study in normal subjects and in patients with Charcot-Marie-Tooth disease.
Neurology. 1974 Jun;24(6):539-46. doi: 10.1212/wnl.24.6.539.
9
Strümpell's familial spastic paraplegia: genetics and neuropathology.
J Neurol Neurosurg Psychiatry. 1974 Jan;37(1):8-20. doi: 10.1136/jnnp.37.1.8.
10
Noninvasive measurement of central sensory and motor conduction.
Neurology. 1985 Apr;35(4):503-9. doi: 10.1212/wnl.35.4.503.
Zotero 插件