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Visual, auditory and somatosensory pathway involvement in hereditary cerebellar ataxia, Friedreich's ataxia and familial spastic paraplegia.视觉、听觉和体感通路在遗传性小脑共济失调、弗里德赖希共济失调和家族性痉挛性截瘫中的受累情况。
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遗传性痉挛性截瘫的中枢运动传导研究

Central motor conduction studies in hereditary spastic paraplegia.

作者信息

Schady W, Dick J P, Sheard A, Crampton S

机构信息

Department of Neurology, Manchester Royal Infirmary, UK.

出版信息

J Neurol Neurosurg Psychiatry. 1991 Sep;54(9):775-9. doi: 10.1136/jnnp.54.9.775.

DOI:10.1136/jnnp.54.9.775
PMID:1659616
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1014514/
Abstract

Central motor conduction (CMC) studies were carried out in 25 patients with hereditary spastic paraplegia (HSP). Responses evoked in the lower limbs by transcranial magnetic stimulation of the motor cortex were bilaterally absent in 33% of the patients and, when recordable, were delayed in 75% of cases. Responses in the upper limbs were mostly normal except for those from the five members of one family, which were considerably delayed. There was no correlation between CMC parameters and age, duration of disease or upper limb hyperreflexia. CMC time to the tibialis anterior correlated with disability in patients with juvenile-onset HSP. It is concluded that CMC studies are not useful in detecting subclinical lesions in hereditary spastic paraplegia but may be of value in identifying subgroups of the disease.

摘要

对25例遗传性痉挛性截瘫（HSP）患者进行了中枢运动传导（CMC）研究。运动皮层经颅磁刺激在下肢诱发的反应在33%的患者中双侧缺失，而在可记录时，75%的病例出现延迟。除了来自一个家族的五名成员的反应明显延迟外，上肢的反应大多正常。CMC参数与年龄、病程或上肢亢进反射之间无相关性。青少年起病的HSP患者中，胫前肌的CMC时间与残疾程度相关。结论是，CMC研究对检测遗传性痉挛性截瘫的亚临床病变无用，但可能对识别该疾病的亚组有价值。