Thomas P K, Jefferys J G, Smith I S, Loulakakis D
J Neurol Neurosurg Psychiatry. 1981 Mar;44(3):243-6. doi: 10.1136/jnnp.44.3.243.
Cervical somatosensory evoked potentials elicited by median nerve stimulation were recorded from 18 cases of hereditary spastic paraplegia. Motor and sensory nerve conduction in the median nerve was normal in each. In one third of the patients no spinal evoked potential was detectable. In the remainder the amplitude of the evoked potential was reduced in comparison with a control series; the latency was not significantly different. These changes suggest that a selective degeneration of the centrally directed axons derived from the dorsal root ganglion cells occurs in this disorder. The findings are discussed in relation to previous reports on the pathological appearances.
对18例遗传性痉挛性截瘫患者进行了正中神经刺激诱发的颈段体感诱发电位记录。每例患者正中神经的运动和感觉神经传导均正常。三分之一的患者未检测到脊髓诱发电位。其余患者与对照组相比，诱发电位幅度降低；潜伏期无显著差异。这些变化表明，在这种疾病中，源自背根神经节细胞的向中枢方向的轴突发生了选择性变性。结合先前关于病理表现的报道对这些发现进行了讨论。
