Landis-Piwowar Kristin R, Chen Di, Cui Qiuzhi Cindy, Minic Vesna, Becker Frederick F, Banik Bimal K, Dou Q Ping
The Prevention Program, Barbara Ann Karmanos Cancer Institute, and Department of Pathology, School of Medicine, Wayne State University, Detroit, MI 48201, USA.
Int J Mol Med. 2006 May;17(5):931-5.
Persistent but relatively limited research has been devoted to the use of compounds related to polycyclic aromatic hydrocarbons (PAH) as anticancer agents. In previous reports, we have described the cytotoxicity of a number of new and novel PAH against human cancer cell lines. However, the involved molecular mechanisms of inducing cell death were not elucidated. In the current study, we describe the apoptotic pathway as apparently playing a crucial role in induced cell death in human leukemia Jurkat T cells by several diamide and diamine PAH that contain chrysene as their core aromatic ring system. Structure-activity relationships were analyzed. Importantly, no effect was demonstrated in a normal, non-transformed line of human natural killer cells. These results provide additional evidence for the potential chemotherapeutic use of PAH.
一直以来，对与多环芳烃（PAH）相关的化合物作为抗癌剂的研究持续存在，但相对有限。在之前的报告中，我们描述了多种新型PAH对人癌细胞系的细胞毒性。然而，诱导细胞死亡所涉及的分子机制尚未阐明。在当前的研究中，我们描述了凋亡途径显然在几种以蒽为核心芳香环系统的二酰胺和二胺PAH诱导人白血病Jurkat T细胞死亡中起着关键作用。我们分析了构效关系。重要的是，在正常的、未转化的人自然杀伤细胞系中未显示出任何作用。这些结果为PAH潜在的化疗用途提供了更多证据。
