Cress Rosemary D, Yin Daixin, Clarke Lisa, Bold Richard, Holly Elizabeth A
California Cancer Registry, Public Health Institute, and Department of Public Health Sciences, UC Davis, Sacramento, CA 95815, USA.
Cancer Causes Control. 2006 May;17(4):403-9. doi: 10.1007/s10552-005-0539-4.
The purpose of the current study was to evaluate survival of patients diagnosed in California with adenocarcinoma of the pancreas by demographic and tumor-related factors.
Through the California Cancer Registry (CCR) we identified all California residents diagnosed with invasive pancreatic adenocarcinoma between 1994 and 2000. Demographic, tumor and treatment information was extracted from the CCR, and socioeconomic status (SES) was assigned based on census block group of residence.
A total of 10,612 eligible patients were identified of whom 1674 (15.8%) underwent surgical resection. Patients of lower SES were less likely to undergo resection and somewhat less likely to survive. Median survival was 3.5 months for patients who were not resected and 13.3 months for those who underwent resection. Adjuvant therapy was associated with a decreased risk of death among patients who underwent resection.
This study is the largest population-based study to date to explore survival from pancreatic cancer among all age groups in a racially diverse population. Median survival was shorter than that reported from other series. Race/ethnicity did not have a significant effect on survival. However patients residing in poor neighborhoods were less likely to undergo resection and somewhat less likely to survive this disease.
本研究旨在通过人口统计学和肿瘤相关因素评估加利福尼亚州诊断为胰腺腺癌患者的生存率。
通过加利福尼亚癌症登记处（CCR），我们确定了1994年至2000年间所有被诊断为浸润性胰腺腺癌的加利福尼亚居民。从CCR中提取人口统计学、肿瘤和治疗信息，并根据居住的普查街区组确定社会经济地位（SES）。
共确定了10612名符合条件的患者，其中1674名（15.8%）接受了手术切除。SES较低的患者接受切除的可能性较小，存活的可能性也略低。未接受切除的患者中位生存期为3.5个月，接受切除的患者为13.3个月。辅助治疗与接受切除的患者死亡风险降低相关。
本研究是迄今为止在种族多样的人群中探索各年龄组胰腺癌生存率的最大规模的基于人群的研究。中位生存期比其他系列报道的要短。种族/民族对生存率没有显著影响。然而，居住在贫困社区的患者接受切除的可能性较小，存活于该疾病的可能性也略低。
