血清素在下丘脑-垂体-肾上腺轴从地塞米松抑制中逃逸的作用。
Role of serotonin in hypothalamo pituitary adrenal axis escape from dexamethasone suppression.
作者信息
Krishnan K R, Ritchie J C, Manepalli A N, Wilson W H, Saunders W B, Venkataraman S S, Carroll B J
机构信息
Department of Psychiatry, Duke University Medical Center, Durham, NC.
出版信息
Prog Neuropsychopharmacol Biol Psychiatry. 1991;15(5):637-42. doi: 10.1016/0278-5846(91)90053-4.
PMID:1659724
Abstract
- The authors investigated the role of serotonin in the hypothalamo pituitary adrenal escape from depression. 2. Maximal dose of fenfluramine was administered to normal individuals pretreated with dexamethasone. 3. Fenfluramine had only a minimal and inconsistent effect on the hypothalamo pituitary adrenal axis in the presence of dexamethasone.
摘要
- 作者研究了血清素在下丘脑-垂体-肾上腺轴摆脱抑郁过程中的作用。2. 对用地塞米松预处理的正常个体给予最大剂量的芬氟拉明。3. 在存在地塞米松的情况下，芬氟拉明对下丘脑-垂体-肾上腺轴只有极小且不一致的影响。
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