Botchin M B, Kaplan J R, Manuck S B, Mann J J
Comparative Medicine Clinical Research Center, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC 27157-1040, USA.
Psychoneuroendocrinology. 1994;19(1):1-11. doi: 10.1016/0306-4530(94)90054-x.
This study was designed to investigate the effect of chronic social stress on central serotonergic responsivity in adult male cynomolgus monkeys (Macaca fascicularis). The influences of social stress and dominance status (social rank) on adrenocorticotropin hormone (ACTH) and cortisol responses to acute administration of an indirect serotonergic agonist (fenfluramine) were evaluated in 75 cynomolgus macaques that were housed in five-member social groups for 28 mo. These groups either remained stable in composition (No-Stress) or had their composition periodically reorganized in the first (Early-Stress) or second (Late-Stress) halves of the study. At the end of the 23rd month, a fenfluramine challenge was done. Animals in the Late-Stress condition had significantly higher ACTH responses compared to those in the No-Stress condition (p < .05) and significantly higher cortisol responses compared to those in the Early-Stress condition (p < .05). No differences between dominant and subordinate animals in ACTH or cortisol responses to challenge were identified. These data suggest that social stress produces a "state"-related augmentation of hypothalamic-pituitary-adrenal responsivity to fenfluramine (serotonergic) challenge in cynomolgus macaques.
本研究旨在调查慢性社会应激对成年雄性食蟹猴（猕猴属）中枢5-羟色胺能反应性的影响。在75只被饲养在五成员社会群体中28个月的食蟹猴中，评估了社会应激和优势地位（社会等级）对促肾上腺皮质激素（ACTH）和皮质醇对急性给予间接5-羟色胺能激动剂（芬氟拉明）反应的影响。这些群体要么组成保持稳定（无应激），要么在研究的前半段（早期应激）或后半段（晚期应激）定期重组其组成。在第23个月末，进行了芬氟拉明激发试验。与无应激条件下的动物相比，晚期应激条件下的动物ACTH反应显著更高（p <.05），与早期应激条件下的动物相比，皮质醇反应显著更高（p <.05）。未发现优势和从属动物在ACTH或皮质醇对激发试验的反应上存在差异。这些数据表明，社会应激会使食蟹猴下丘脑-垂体-肾上腺对芬氟拉明（5-羟色胺能）激发试验的反应产生与“状态”相关的增强。
