选择成人对成人活体肝移植的肝移植候选者，作为终末期肝病的唯一手术选择。

Selection of liver-transplant candidates for adult-to-adult living donor liver transplantation as the only surgical option for end-stage liver disease.

作者信息

Yamashiki Noriyo, Sugawara Yasuhiko, Tamura Sumihito, Kaneko Junichi, Nojiri Kayo, Omata Masao, Makuuchi Masatoshi

机构信息

Organ Transplantation Service, University of Tokyo, Graduate School of Medicine, Tokyo, Japan.

出版信息

Liver Transpl. 2006 Jul;12(7):1077-83. doi: 10.1002/lt.20759.

DOI:10.1002/lt.20759

PMID:16598784

Abstract

The selection of living donor liver transplantation (LDLT) recipients in regions where deceased donor liver transplantation (DDLT) is rarely performed might be different from that in other centers at which LDLT is an alternative option to DDLT. Records of adult (age > or = 18 yr) patients referred to our center were reviewed to analyze the selection process of LDLT candidates. Among the 533 LDLT candidates, 165 (31%) were rejected due to recipient issues. Advanced hepatocellular carcinoma (HCC) was the most common reason for rejection (n = 55). Among the remaining recipients, 120 patients (22%) were rejected due to donor issues. LDLT was eventually performed in 249 (47%) of the evaluated recipients. There are few options for candidates who are unable to find live donors in regions where DDLT is unrealistic. A more effective and precise approach to recipient and donor evaluation should be pursued.

摘要

在尸体供肝肝移植（DDLT）很少开展的地区，活体供肝肝移植（LDLT）受者的选择可能与其他将LDLT作为DDLT替代方案的中心有所不同。我们回顾了转诊至本中心的成年（年龄≥18岁）患者记录，以分析LDLT候选者的选择过程。在533名LDLT候选者中，165名（31%）因受者问题被拒绝。晚期肝细胞癌（HCC）是最常见的拒绝原因（n = 55）。在其余受者中，120名患者（22%）因供者问题被拒绝。最终，249名（47%）评估受者接受了LDLT。在DDLT不现实的地区，无法找到活体供者的候选者选择很少。应寻求一种更有效、精确的受者和供者评估方法。