London Leslie, Bourne David, Sayed Rauf, Eastman Roland
Occupational and Environmental Health Research Unit, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa.
Arch Environ Health. 2004 Nov;59(11):575-80. doi: 10.1080/00039890409603436.
Although organophosphate (OP) insecticides have been recognized as having neuropathic potential, a relationship with Guillain-Barre syndrome (GBS) has not been previously confirmed. A cluster of 7 cases of GBS was noted over an 11-yr period in an isolated farming region in the Northern Cape Province of South Africa, an area subject to intensive aerial application of OP insecticides. Observed cases were more than 4 times higher than expected based on a Poisson probability distribution. Four cases were clustered in an area where the topography showed a marked hollow, and where spray drift of aerial OP insecticides was anticipated. The rate of GBS in this subcluster was more than 14 times higher than expected. The authors explored the hypothesis that aerial OP insecticide application was related to the raised incidence of GBS in this area and made suggestions for future research.
尽管有机磷杀虫剂已被认为具有神经病变的潜在风险，但此前尚未证实其与吉兰-巴雷综合征（GBS）之间存在关联。在南非北开普省一个偏远的农业地区，在11年的时间里发现了7例GBS病例聚集，该地区大量使用有机磷杀虫剂进行空中喷洒。根据泊松概率分布，观察到的病例数比预期高出4倍多。有4例病例集中在一个地势明显低洼的区域，预计该区域会出现空中喷洒有机磷杀虫剂的喷雾漂移现象。该子集群中的GBS发病率比预期高出14倍多。作者探讨了空中喷洒有机磷杀虫剂与该地区GBS发病率升高之间存在关联的假设，并为未来的研究提出了建议。
