Chiu Pai-Yi, Chung Ching-Lung
Department of Neurology, Taichung Linshin Hospital, National Chung Cheng University, Taiwan.
Acta Neurol Taiwan. 2006 Mar;15(1):21-5.
To compare the prevalence of delusions in different stages in Taiwanese patients with very mild to moderate Alzheimer's disease (AD).
A consecutive series of 91 patients with probable Alzheimer's disease visited the dementia clinic in a regional hospital in mid-Taiwan were enrolled in this study. All patients were examined with the Neuropsychiatric Inventory (NPI), the Cognitive Abilities Screening Instrument (CASI), and the Clinical Dementia Rating (CDR) scale.
The prevalence rate of any delusion in very mild, mild and moderate AD was 35.2%. Delusions of other persons are stealing was most common (27.5%), followed by delusions of self is in danger (15.4%), house is not his/her home (5.5%), family plans to abandon him/her (4.4%), spouse is having an affair (2.2%), an unwelcome guest is living in the house (2.2%), media persons are in the house (2.2%), and others aren't who they claim (1.1%). The prevalence rates of delusions is 33% in very mild AD, 30% in mild AD and 48% in moderate AD. AD (P>0.05).
Delusions are common neuropsychiatric symptoms in very early stage as well as in later stages of Taiwanese patients with AD and it deserves the attention that delusions may be characteristic of very mild AD.
比较台湾极轻度至中度阿尔茨海默病（AD）患者不同阶段妄想的患病率。
本研究纳入了台湾中部一家地区医院痴呆门诊连续就诊的91例可能患有阿尔茨海默病的患者。所有患者均接受神经精神科问卷（NPI）、认知能力筛查工具（CASI）和临床痴呆评定量表（CDR）检查。
极轻度、轻度和中度AD患者中任何妄想的患病率为35.2%。他人偷窃妄想最为常见（27.5%），其次是自身处于危险妄想（15.4%）、房子不是自己家的妄想（5.5%）、家人计划抛弃自己的妄想（4.4%）、配偶有外遇的妄想（2.2%）、房子里有不受欢迎的客人的妄想（2.2%）、媒体人员在房子里的妄想（2.2%）以及他人并非其所称身份的妄想（1.1%）。极轻度AD患者妄想的患病率为33%，轻度AD患者为30%，中度AD患者为48%。AD（P>0.05）。
妄想是台湾AD患者极早期以及后期常见的神经精神症状，妄想可能是极轻度AD的特征这一点值得关注。
