Eager N S, Rowe A, Brickell P M
Department of Biochemistry and Molecular Biology, University College and Middlesex School of Medicine, London, UK.
FEBS Lett. 1991 Nov 4;292(1-2):103-6. doi: 10.1016/0014-5793(91)80844-s.
The chicken cRXR nuclear receptor is a member of the steroid/thyroid hormone receptor superfamily. In this paper we show that cRXR can transactivate gene expression in response to retinoic acid, but that its sensitivity to retinoic acid is lower than that of the hRAR-beta receptor. We have also compared the ability of cRXR and hRAR-beta to respond to a panel of other retinoids. Unlike hRAR-beta, cRXR failed to respond to the naturally occurring retinoid 3,4-didehydro-retinoic acid or to the synthetic retinoid TTNPB, both of which share the ability of retinoic acid to induce digit duplications when locally applied to chick limb buds.
鸡的类视黄醇X受体（cRXR）核受体是类固醇/甲状腺激素受体超家族的成员。在本文中，我们表明cRXR能响应视黄酸而反式激活基因表达，但其对视黄酸的敏感性低于人视黄酸受体β（hRAR-β）。我们还比较了cRXR和hRAR-β对一组其他类维生素A的反应能力。与hRAR-β不同，cRXR对天然存在的类维生素A 3,4-二脱氢视黄酸或合成类维生素A TTNPB均无反应，这两种物质在局部应用于鸡胚肢芽时都具有视黄酸诱导指重复的能力。
