在直接经皮冠状动脉介入治疗和糖蛋白IIb/IIIa抑制剂时代，心肌梗死后左心室血栓形成的发生率。一项前瞻性观察研究。
Incidence of post myocardial infarction left ventricular thrombus formation in the era of primary percutaneous intervention and glycoprotein IIb/IIIa inhibitors. A prospective observational study.
作者信息
Rehan Arshad, Kanwar Manpreet, Rosman Howard, Ahmed Sujood, Ali Arshad, Gardin Julius, Cohen Gerald
机构信息
Department of Cardiology, St John Hospital and Medical Centre, Wayne State University, Detroit, Michigan 48230, USA.
出版信息
Cardiovasc Ultrasound. 2006 Apr 6;4:20. doi: 10.1186/1476-7120-4-20.
BACKGROUND
Before the widespread use of primary percutaneous coronary intervention (PCI) and glycoprotein IIb/IIIa inhibitors (GP IIb/IIIa) left ventricular (LV) thrombus formation had been reported to complicate up to 20% of acute myocardial infarctions (AMI). The incidence of LV thrombus formation with these treatment modalities is not well known.
METHODS
92 consecutive patients with ST-elevation AMI treated with PCI and GP IIb/IIIa inhibitors underwent 2-D echocardiograms, with and without echo contrast agent, within 24-72 hours.
RESULTS
Only 4/92 (4.3%) had an LV thrombus, representing a significantly lower incidence than that reported in the pre-PCI era. Use of contrast agents did not improve detection of LV thrombi in our study.
CONCLUSION
The incidence of LV thrombus formation after acute MI, in the current era of rapid reperfusion, is lower than what has been historically reported.
背景
在原发性经皮冠状动脉介入治疗（PCI）和糖蛋白IIb/IIIa抑制剂（GP IIb/IIIa）广泛应用之前，据报道，左心室（LV）血栓形成会使高达20%的急性心肌梗死（AMI）病情复杂化。目前尚不清楚采用这些治疗方式时LV血栓形成的发生率。
方法
92例接受PCI和GP IIb/IIIa抑制剂治疗的ST段抬高型AMI连续患者在24至72小时内接受了二维超声心动图检查，检查时使用和未使用超声造影剂。
结果
仅4/92（4.3%）患者出现LV血栓，这一发生率显著低于PCI时代之前报道的发生率。在我们的研究中，使用造影剂并未提高LV血栓的检出率。
结论
在当前快速再灌注时代，急性心肌梗死后LV血栓形成的发生率低于历史报道。
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