Lu Ling, Zhang Long-lian, Li Guo-jun, Guo Wen-rui, Liang Wan-nian, Wei Zheng
Fengtai Center for Disease Control and Prevention, Beijing 100071, China.
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2006 Jan;24(1):31-4.
To investigate the systemic changes of iron metabolism following manganese exposure.
Ninety-seven welders and 91 workers with no history of exposure to manganese were recruited from the same factory in Beijing serving as the exposure group and the control group respectively. The welding rods used were type J422. The concentration of the manganese in the air of the work place was determined respectively with the national standard method. The serum iron and manganese, ferritin, transferrin and transferrin receptors were measured with the graphite furnace atomic absorption spectrophotometry and ELISA in both groups.
The permissible concentration-STEL of ambient Mn in welders' breathing zone ranged from 0.53 mg/m(3) to 2.19 mg/m(3), while the permissible concentration-TWA of ambient Mn was between 0.29 mg/m(3) and 0.92 mg/m(3) in the breathing zone of the workplace. Serum Mn and Fe concentrations in welders were about 1.40 times (P < 0.0l) and 1.2 times (P < 0.01), respectively, higher than those of control subjects. At the same time, the transferrin concentrations in serum were significantly higher (about 1.2 times, P < 0.05) in welders than in controls. In contrast, transferrin receptors were significantly lower (about 1.2 times) in exposed subjects than controls (P = 0.001). There was no difference in serum ferritin between the two groups (P = 0.112). Although there was no significant trend, the serum ferritin level was increased by 18% in comparison with that of the control. The abnormal percentage of serum Fe and Serum Mn in welders were 55.67% and 67.01% respectively, higher than those of control subjects. In addition, the correlations between all indicators and the duration of employment were not observed.
The long term exposure to the manganese can induce the disorder of the iron metabolism, which is found in the expression of increase of the serum iron and transferrin as well as the decrease of transferrin receptors.
探讨锰暴露后铁代谢的全身变化。
从北京同一家工厂招募97名焊工和91名无锰暴露史的工人，分别作为暴露组和对照组。使用的焊条为J422型。采用国家标准方法分别测定工作场所空气中的锰浓度。两组均采用石墨炉原子吸收分光光度法和酶联免疫吸附测定法测定血清铁、锰、铁蛋白、转铁蛋白和转铁蛋白受体。
焊工呼吸带空气中锰的短时间接触容许浓度范围为0.53mg/m³至2.19mg/m³，而工作场所呼吸带空气中锰的时间加权平均容许浓度在0.29mg/m³至0.92mg/m³之间。焊工血清锰和铁浓度分别比对照组高约1.40倍（P<0.01）和1.2倍（P<0.01）。同时，焊工血清中转铁蛋白浓度显著高于对照组（约1.2倍，P<0.05）。相比之下，暴露组转铁蛋白受体显著低于对照组（约1.2倍）（P = 0.001）。两组血清铁蛋白无差异（P = 0.112）。虽然无显著趋势，但血清铁蛋白水平比对照组升高了18%。焊工血清铁和血清锰的异常百分比分别为55.67%和67.01%，高于对照组。此外，未观察到所有指标与就业年限之间的相关性。
长期接触锰可导致铁代谢紊乱，表现为血清铁和转铁蛋白升高以及转铁蛋白受体降低。
