Rénia Laurent, Potter Sarah M, Mauduit Marjorie, Rosa Daniela Santoro, Kayibanda Michèle, Deschemin Jean-Christophe, Snounou Georges, Grüner Anne Charlotte
Department of Immunology, Institut Cochin, INSERM U567, CNRS UMR 8104, Université René Descartes, Hôpital Cochin, Paris, France.
Int J Parasitol. 2006 May 1;36(5):547-54. doi: 10.1016/j.ijpara.2006.02.007. Epub 2006 Mar 10.
Malaria remains a major global health problem and cerebral malaria (CM) is one of the most serious complications of this disease. Recent years have seen important advances in our understanding of the pathogenesis of cerebral malaria. Parasite sequestration, a hallmark of this syndrome, is thought to be solely responsible for the pathological process. However, this phenomenon cannot explain all aspects of the pathogenesis of CM. The use of an animal model, Plasmodium berghei ANKA in mice, has allowed the identification of specific pathological components of CM. Although multiple pathways may lead to CM, an important role for CD8+ T cells has been clarified. Other cells, including platelets, and mediators such as cytokines also have an important role. In this review we have focused on the role of T cells, and discuss what remains to be studied to understand the pathways by which these cells mediate CM.
疟疾仍然是一个主要的全球健康问题，而脑型疟疾（CM）是该疾病最严重的并发症之一。近年来，我们对脑型疟疾发病机制的理解取得了重要进展。寄生虫滞留是该综合征的一个标志，被认为是病理过程的唯一原因。然而，这种现象无法解释脑型疟疾发病机制的所有方面。使用动物模型，即小鼠体内的伯氏疟原虫ANKA，已经能够识别脑型疟疾的特定病理成分。尽管多种途径可能导致脑型疟疾，但CD8 + T细胞的重要作用已经明确。其他细胞，包括血小板，以及细胞因子等介质也发挥着重要作用。在这篇综述中，我们重点关注了T细胞的作用，并讨论了为了解这些细胞介导脑型疟疾的途径仍有待研究的内容。
