一种新型Vi结合疫苗在鼠伤寒沙门氏菌病小鼠模型中的评估。
Evaluation of a novel Vi conjugate vaccine in a murine model of salmonellosis.
作者信息
Hale Christine, Bowe Frances, Pickard Derek, Clare Simon, Haeuw Jean-Francois, Powers Ultan, Menager Nathalie, Mastroeni Pietro, Dougan Gordon
机构信息
The Wellcome Trust Genome Campus, The Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK.
出版信息
Vaccine. 2006 May 15;24(20):4312-20. doi: 10.1016/j.vaccine.2006.03.002. Epub 2006 Mar 20.
Abstract
Immunisation of BALB/c mice with a vaccine containing Vi polysaccharide conjugated to the Klebsiella pneumoniae outer membrane 40 kDa protein (rP40), in combination with Escherichia coli heat-labile toxin adjuvant (LT), elicited anti-Vi IgG antibodies after administration using different routes. Testing of the immune serum in opsonisation assays demonstrated the specific enhancement of Vi-positive bacterial uptake by cultured murine bone marrow derived macrophages. Intra-peritoneal challenge of mice immunised with the Vi-based vaccine elicited a degree of protection against virulent Vi+ Salmonella enterica serovar typhimurium (S. typhimurium). In contrast, Vi vaccination did not confer protection against oral challenge with virulent Vi-positive S. typhimurium or S. dublin.
摘要
用含有与肺炎克雷伯菌外膜40 kDa蛋白（rP40）偶联的Vi多糖的疫苗免疫BALB/c小鼠，并联合大肠杆菌不耐热毒素佐剂（LT），通过不同途径给药后可诱导产生抗Vi IgG抗体。在调理吞噬试验中对免疫血清进行检测，结果表明培养的小鼠骨髓来源巨噬细胞对Vi阳性细菌的摄取有特异性增强。用基于Vi的疫苗免疫的小鼠进行腹腔攻毒，可诱导产生一定程度的针对强毒Vi+鼠伤寒沙门氏菌（鼠伤寒沙门菌）的保护作用。相比之下，Vi疫苗接种不能对强毒Vi阳性鼠伤寒沙门菌或都柏林沙门菌的口服攻毒提供保护。
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