Patino Luis, Chakarov Vihren, Schulte-Mönting Jürgen, Hepp-Reymond Marie-Claude, Kristeva Rumyana
Neurological Clinic, University Freiburg, Breisacherstrasse 64, Freiburg 79106, Germany.
Neurosci Lett. 2006 Jul 3;401(3):214-8. doi: 10.1016/j.neulet.2006.03.027. Epub 2006 Apr 4.
Little is known about the influence of the afferent peripheral feedback on the sensorimotor cortex activation. To answer this open question we investigated the alpha and beta band task-related spectral power decreases (TRPow) in the deafferented patient G.L. and compared the results to those of six healthy subjects. The patient has been deafferented up to the nose for 24 years but her motor fibers are unaffected and she can perform complex motor tasks under visual control. We recorded EEG (58 scalp positions) as well as the exerted force during a visuomotor task. The subjects had to maintain in precision grip an isometric force at 15% of the maximal voluntary contraction. In the patient we found a significantly higher alpha band spectral power during rest and larger alpha TRPow decreases during the motor task when compared to the healthy subjects' data. In contrast, we did not observe any significant differences between patient and controls for the beta band TRPow. The results indicate an altered functional alpha band network state in the patient, probably due to the chronic deafferentation leading to a deep 'idling' state of the contralateral sensorimotor area.
关于传入外周反馈对感觉运动皮层激活的影响，目前所知甚少。为了回答这个开放性问题，我们研究了去传入神经患者G.L.中与任务相关的α和β波段频谱功率降低（TRPow）情况，并将结果与六名健康受试者的结果进行了比较。该患者已经去传入神经达24年，直至鼻子部位，但她的运动纤维未受影响，并且她能够在视觉控制下执行复杂的运动任务。我们记录了在视觉运动任务期间的脑电图（58个头皮位置）以及施加的力。受试者必须在精确抓握时保持最大自主收缩15%的等长力。与健康受试者的数据相比，我们发现患者在休息时α波段频谱功率显著更高，并且在运动任务期间α波段TRPow降低幅度更大。相比之下，我们未观察到患者与对照组在β波段TRPow方面存在任何显著差异。结果表明患者的功能性α波段网络状态发生了改变，这可能是由于慢性去传入神经导致对侧感觉运动区处于深度“闲置”状态所致。
