Friedman Peter A, Goodman William G
Univ. of Pittsburgh School of Medicine, Dept. of Pharmacology, E-1347 Biomedical Science Tower, Pittsburgh, PA 15261, USA.
Am J Physiol Renal Physiol. 2006 May;290(5):F975-84. doi: 10.1152/ajprenal.00336.2005.
This review considers many new basic and clinical aspects of parathyroid hormone (PTH). We focus especially on the identification of PTH fragments and how they may relate to renal failure, diagnosis, and treatment of secondary hyperparathyroidism and renal osteodystrophy. The biosynthesis and metabolism of PTH, measurement of circulating forms of PTH, the effects of PTH on receptor activation and turnover, the relationship between PTH levels and bone turnover in renal failure in humans, and the involvement of PTH in experimental models of renal failure are discussed. Despite these developments in understanding the etiology of renal failure and the availability of new assays for bioactive PTH, no adequate surrogate for bone biopsy and quantitative bone histomorphometry has been developed.
本综述探讨了甲状旁腺激素（PTH）许多新的基础和临床方面。我们特别关注PTH片段的鉴定以及它们与肾衰竭、继发性甲状旁腺功能亢进和肾性骨营养不良的诊断及治疗之间的关系。文中讨论了PTH的生物合成与代谢、循环中PTH形式的测量、PTH对受体激活和更新的影响、人类肾衰竭时PTH水平与骨转换的关系以及PTH在肾衰竭实验模型中的作用。尽管在理解肾衰竭病因方面有了这些进展，并且有了用于生物活性PTH的新检测方法，但尚未开发出足以替代骨活检和定量骨组织形态计量学的方法。
