• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

鼓励开展早期临床经验，采用故意延迟的临时胎儿镜气管闭塞术对危及生命的左右先天性膈疝进行产前治疗。

Encouraging early clinical experience with deliberately delayed temporary fetoscopic tracheal occlusion for the prenatal treatment of life-threatening right and left congenital diaphragmatic hernias.

作者信息

Kohl Thomas, Gembruch Ulrich, Filsinger Barbara, Hering Rudolf, Bruhn Jorgen, Tchatcheva Kristina, Aryee Sebastian, Franz Axel, Heep Axel, Muller Andreas, Bartmann Peter, Loff Stefan, Hosie Stuart, Neff Wolfgang, Schaible Thomas

机构信息

German Center for Fetal Surgery and Minimally Invasive Therapy, University Hospital of Bonn, Germany.

出版信息

Fetal Diagn Ther. 2006;21(3):314-8. doi: 10.1159/000091363.

DOI:10.1159/000091363
PMID:16601345
Abstract

OBJECTIVE

In order to assess the effect of deliberately delayed percutaneous fetoscopic tracheal occlusion on survival of fetuses with life-threatening congenital diaphragmatic hernia.

METHODS

Eight fetuses with life-threatening congenital diaphragmatic hernia underwent fetoscopic tracheal balloon occlusion between 29 + 0 and 32 + 4 weeks of gestation. Delayed occlusion was chosen in order to minimize potentially negative pulmonary effects from premature delivery as a result of fetal surgery. In addition, we wanted to become able to provide all available postnatal intensive care treatment means in these patients.

RESULTS

Six of the 8 fetuses survived to discharge from hospital.

CONCLUSION

Delayed fetoscopic tracheal balloon occlusion may be rewarded with lung growth sufficient to allow survival of fetuses with life-threatening congenital diaphragmatic hernia.

摘要

目的

评估故意延迟经皮胎儿镜气管闭塞术对患有危及生命的先天性膈疝胎儿存活率的影响。

方法

8例患有危及生命的先天性膈疝的胎儿在妊娠29 + 0至32 + 4周期间接受了胎儿镜气管球囊闭塞术。选择延迟闭塞是为了尽量减少因胎儿手术导致早产而产生的潜在负面肺部影响。此外，我们希望能够为这些患者提供所有可用的产后重症监护治疗手段。

结果

8例胎儿中有6例存活至出院。

结论

延迟胎儿镜气管球囊闭塞术可能会使肺部充分生长，从而使患有危及生命的先天性膈疝的胎儿存活。

相似文献

1
Encouraging early clinical experience with deliberately delayed temporary fetoscopic tracheal occlusion for the prenatal treatment of life-threatening right and left congenital diaphragmatic hernias.鼓励开展早期临床经验，采用故意延迟的临时胎儿镜气管闭塞术对危及生命的左右先天性膈疝进行产前治疗。
Fetal Diagn Ther. 2006;21(3):314-8. doi: 10.1159/000091363.
2
Fetoscopic temporary tracheal occlusion by means of detachable balloon for congenital diaphragmatic hernia.
Am J Obstet Gynecol. 2001 Sep;185(3):730-3. doi: 10.1067/mob.2001.117344.
3
Balloon removal after fetoscopic endoluminal tracheal occlusion for congenital diaphragmatic hernia.先天性膈疝胎儿镜下腔内气管阻塞术后球囊移除
Am J Obstet Gynecol. 2017 Jul;217(1):78.e1-78.e11. doi: 10.1016/j.ajog.2017.02.041. Epub 2017 Mar 3.
4
A randomized trial of fetal endoscopic tracheal occlusion for severe fetal congenital diaphragmatic hernia.胎儿内镜下气管闭塞治疗严重胎儿先天性膈疝的随机试验。
N Engl J Med. 2003 Nov 13;349(20):1916-24. doi: 10.1056/NEJMoa035005.
5
Fetal lung-to-head ratio in the prediction of survival in severe left-sided diaphragmatic hernia treated by fetal endoscopic tracheal occlusion (FETO).胎儿肺头比在预测经胎儿内镜气管阻塞术（FETO）治疗的严重左侧膈疝患儿生存率中的应用
Am J Obstet Gynecol. 2006 Dec;195(6):1646-50. doi: 10.1016/j.ajog.2006.04.004. Epub 2006 Jun 12.
6
Early fetoscopic tracheal occlusion for extremely severe pulmonary hypoplasia in isolated congenital diaphragmatic hernia: preliminary results.孤立性先天性膈疝中极度严重肺发育不良的早期经腹胎儿镜气管阻塞：初步结果。
Ultrasound Obstet Gynecol. 2013 Jul;42(1):70-6. doi: 10.1002/uog.12414.
7
Correction of congenital diaphragmatic hernia in utero IX: fetuses with poor prognosis (liver herniation and low lung-to-head ratio) can be saved by fetoscopic temporary tracheal occlusion.胎儿先天性膈疝的宫内矫治IX：预后不良（肝脏疝出和低肺头比）的胎儿可通过胎儿镜下临时气管闭塞术获救。
J Pediatr Surg. 1998 Jul;33(7):1017-22; discussion 1022-3. doi: 10.1016/s0022-3468(98)90524-3.
8
Fetoscopic temporary tracheal occlusion for congenital diaphragmatic hernia: prelude to a randomized, controlled trial.胎儿镜下先天性膈疝的临时气管阻塞：一项随机对照试验的前奏。
J Pediatr Surg. 2003 Jul;38(7):1012-20. doi: 10.1016/s0022-3468(03)00182-9.
9
[Antenatal treatment of congenital diaphragmatic hernia: an update].
Arch Pediatr. 2008 Aug;15(8):1320-5. doi: 10.1016/j.arcped.2008.04.034. Epub 2008 Jun 30.
10
Fetal pulmonary response after fetoscopic tracheal occlusion for severe isolated congenital diaphragmatic hernia.胎儿镜下气管阻塞术治疗严重先天性膈疝的胎儿肺脏反应。
Obstet Gynecol. 2012 Jan;119(1):93-101. doi: 10.1097/AOG.0b013e31823d3aea.

引用本文的文献

1
Case Report: Fetoscopic Laparoschisis (FETO-LAP)-A New Therapeutic Route to Explore for Fetuses with Severe Diaphragmatic Hernias.病例报告：胎儿镜下先天性腹壁裂（FETO-LAP）——探索治疗严重膈疝胎儿的新治疗途径。
Children (Basel). 2023 Oct 30;10(11):1758. doi: 10.3390/children10111758.
2
Lifesaving Treatments for the Tiniest Patients-A Narrative Description of Old and New Minimally Invasive Approaches in the Arena of Fetal Surgery.为最小患者的救命治疗——胎儿手术领域新旧微创方法的叙述性描述
Children (Basel). 2022 Dec 28;10(1):67. doi: 10.3390/children10010067.
3
Challenges and Pitfalls: Performing Clinical Trials in Patients With Congenital Diaphragmatic Hernia.
挑战与陷阱：先天性膈疝患者的临床试验
Front Pediatr. 2022 Apr 15;10:852843. doi: 10.3389/fped.2022.852843. eCollection 2022.
4
The Use of Fetal Bronchoscopy in the Diagnosis and Management of a Suspected Obstructive Lung Mass.胎儿支气管镜检查在疑似阻塞性肺肿块诊断和管理中的应用
AJP Rep. 2018 Jul;8(3):e195-e200. doi: 10.1055/s-0038-1673378. Epub 2018 Sep 25.
5
Minimally invasive fetoscopic interventions: an overview in 2010.微创胎儿镜介入术：2010 年概述。
Surg Endosc. 2010 Aug;24(8):2056-67. doi: 10.1007/s00464-010-0879-3. Epub 2010 Mar 17.