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胎儿支气管镜检查在疑似阻塞性肺肿块诊断和管理中的应用

The Use of Fetal Bronchoscopy in the Diagnosis and Management of a Suspected Obstructive Lung Mass.

作者信息

Chon Andrew H, Stein James E, Gerstenfeld Tammy, Wang Larry, Vazquez Walter D, Chmait Ramen H

机构信息

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, California.

Department of Pediatric Surgery, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, California.

出版信息

AJP Rep. 2018 Jul;8(3):e195-e200. doi: 10.1055/s-0038-1673378. Epub 2018 Sep 25.

Abstract

Etiologies of fetal lung anomalies include congenital pulmonary airway malformation (CPAM), intra- or extralobar pulmonary sequestration, congenital high airway obstruction syndrome (CHAOS), bronchogenic cyst, and bronchial atresia. Fetal tracheobronchoscopy has been reported both as a diagnostic and therapeutic procedure in the setting of severe congenital lung lesions. In this case report, prenatal imaging of a fetus with a large chest mass was suspicious for an obstructive bronchial lesion. The absence of visible normal lung tissue on the right side and mass effect on the left side raised the concern for pulmonary hypoplasia. After antenatal betamethasone and a period observation, hydropic changes developed. Fetal tracheobronchoscopy was then performed in an effort to identify and decompress the suspected obstructive bronchial lesion. Other than release of bronchial debris, no anatomical abnormalities were visualized. However, the right lung lesion and mediastinal shift both decreased after the fetal bronchoscopy. The newborn underwent postnatal resection of a CPAM Type II and is doing well. We hypothesize that fetal tracheobronchoscopy provided the following potential diagnostic and therapeutic benefits: (1) exclusion of an obstructive bronchial lesion; (2) disimpaction of bronchial debris from the saline lavage that we posit may have contributed to the rapid reduction in CPAM size.

摘要

胎儿肺部异常的病因包括先天性肺气道畸形(CPAM)、肺叶内或肺叶外肺隔离症、先天性高位气道梗阻综合征(CHAOS)、支气管囊肿和支气管闭锁。胎儿气管支气管镜检查已被报道可用于严重先天性肺部病变的诊断和治疗。在本病例报告中,一名胸部有巨大肿块胎儿的产前影像学检查怀疑存在阻塞性支气管病变。右侧未见正常肺组织且左侧有占位效应,这引发了对肺发育不全的担忧。产前给予倍他米松并经过一段时间观察后,出现了水肿改变。随后进行了胎儿气管支气管镜检查,以识别并解除疑似阻塞性支气管病变。除了清除支气管碎片外,未发现解剖学异常。然而,胎儿支气管镜检查后,右肺病变和纵隔移位均有所减轻。新生儿出生后接受了II型先天性肺气道畸形切除术,目前情况良好。我们推测胎儿气管支气管镜检查具有以下潜在的诊断和治疗益处:(1)排除阻塞性支气管病变;(2)通过盐水灌洗清除支气管碎片,我们认为这可能有助于先天性肺气道畸形体积的迅速缩小。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf3a/6156116/25e38099ca82/10-1055-s-0038-1673378-i170057-1.jpg

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