Desmarais Paul L, Cox Cheryl L
University of Central Florida, School of Nursing, Orlando, Fla 32816-2210, USA.
J Cardiovasc Nurs. 2006 Mar-Apr;21(2):118-22.
To document the impact of cardiac rehabilitation on morbidity and mortality patterns relative to the type (ie, Q wave vs non-Q wave) of myocardial infarction (MI).
Data (ie, diagnoses, cardiac risk factors, hospital readmissions, reinfarctions, comorbidity, and mortality) spanning 5 years from the time of initial diagnosis of MI were abstracted from the medical records of 357 and 163 patients with Q wave and non-Q wave MI, respectively, who participated in cardiac rehabilitation. Survival analyses were used to test the hypotheses of no difference in time to reinfarction and/or death between persons who had a Q wave MI and those who had a non-Q wave MI.
Although the numbers of reinfarctions (n = 64) and deaths (n = 38) within the sample were small and did not allow for statistical significance of findings, trends suggest that individuals who had non-Q wave MI had better survival rates for the first 3 years after cardiac rehabilitation (1.8% vs 4.5%) than did those who had Q wave MI. Reinfarction rates, however, were similar for both groups.
The small number of deaths and reinfarctions may be indicative of selection biases inherent in the current protocols that define the exclusion criteria for participation in cardiac rehabilitation. The results of this study call for a reevaluation of studies that have touted the efficacy of cardiac rehabilitation through the comparison of participating and nonparticipating cohorts. This study points to the need for a national database that would allow for a more comprehensive quality-controlled data collection that would provide more meaningful evaluation of direct and indirect effects of risk variables and intervention development.
记录心脏康复对与心肌梗死(MI)类型(即Q波型与非Q波型)相关的发病率和死亡率模式的影响。
从分别参与心脏康复的357例Q波型心肌梗死患者和163例非Q波型心肌梗死患者的病历中提取自首次诊断心肌梗死后5年的数据(即诊断、心脏危险因素、再次入院、再梗死、合并症和死亡率)。生存分析用于检验Q波型心肌梗死患者和非Q波型心肌梗死患者在再梗死和/或死亡时间上无差异的假设。
尽管样本中的再梗死(n = 64)和死亡(n = 38)人数较少,无法使研究结果具有统计学意义,但趋势表明,非Q波型心肌梗死患者在心脏康复后的前3年生存率(1.8%对4.5%)优于Q波型心肌梗死患者。然而,两组的再梗死率相似。
死亡和再梗死人数较少可能表明当前定义心脏康复参与排除标准的方案中存在固有的选择偏倚。本研究结果呼吁对那些通过比较参与组和非参与组来宣扬心脏康复疗效的研究进行重新评估。本研究指出需要建立一个国家数据库,以便进行更全面的质量控制数据收集,从而对风险变量和干预措施开发的直接和间接影响提供更有意义的评估。