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Higher potency of the synthetic retinoid MX3350-1 compared to the natural all-trans-retinoic acid in modulation of cell cycle and induction of apoptosis in head and neck squamous carcinoma cells.

作者信息

Chun K-H, Lotan R

出版信息

Cell Death Differ. 2006 Oct;13(10):1830-2. doi: 10.1038/sj.cdd.4401917. Epub 2006 Apr 7.

DOI:10.1038/sj.cdd.4401917
PMID:16601752
Abstract
摘要

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1
Higher potency of the synthetic retinoid MX3350-1 compared to the natural all-trans-retinoic acid in modulation of cell cycle and induction of apoptosis in head and neck squamous carcinoma cells.
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Induction of apoptosis by the synthetic retinoid MX3350-1 through extrinsic and intrinsic pathways in head and neck squamous carcinoma cells.合成类视黄醇MX3350-1通过外在和内在途径诱导头颈部鳞状癌细胞凋亡。
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Overexpression of retinoic acid receptor beta in head and neck squamous cell carcinoma cells increases their sensitivity to retinoid-induced suppression of squamous differentiation by retinoids.头颈部鳞状细胞癌细胞中视黄酸受体β的过表达增加了它们对类视黄醇诱导的类视黄醇抑制鳞状分化的敏感性。
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Identification of retinoid-modulated proteins in squamous carcinoma cells using high-throughput immunoblotting.利用高通量免疫印迹法鉴定鳞状癌细胞中类视黄醇调节蛋白
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[A novel retinoid CD437 induces apoptosis of human epidermoid carcinoma A431 cells].一种新型维甲酸CD437诱导人表皮样癌A431细胞凋亡
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Synthetic retinoid CD437 promotes rapid apoptosis in malignant human epidermal keratinocytes and G1 arrest in their normal counterparts.合成维甲酸CD437可促进恶性人表皮角质形成细胞快速凋亡,并使其正常对应细胞停滞于G1期。
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