代谢综合征：胰岛素敏感性与过氧化物酶体增殖物激活受体（PPARs）在糖类和脂质代谢中的作用之间的关系。
The metabolic syndrome: relationship between insulin sensitivity and the role of peroxisome proliferator-activated receptors (PPARs) in saccharide and lipid metabolism.
作者信息
Yahia Rabha Ben, Lichnovská Radka, Brychta Tomás
机构信息
Institute of Physiology, Palacký University, 775 15 Olomouc, Czech Republic.
出版信息
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2005 Dec;149(2):237-41.
PMID:16601762
Abstract
Peroxisome proliferator-activated receptors (PPARs) are subgroups of nuclear hormonal receptors of transcripting factors mostly found in adipose tissue. They are described as important regulators of lipid and saccharide metabolism including insulin sensitivity; therefore they are taken as marker of metabolic syndrome. Their synthetic ligands could be used as drugs for insulin resistance and type 2 diabetes mellitus.
摘要
过氧化物酶体增殖物激活受体（PPARs）是转录因子核激素受体的亚组，主要存在于脂肪组织中。它们被认为是脂质和糖类代谢的重要调节因子，包括胰岛素敏感性；因此，它们被视为代谢综合征的标志物。其合成配体可作为治疗胰岛素抵抗和2型糖尿病的药物。
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