由2-硝基芴诱导的染色体突变导致环丙沙星耐药性的产生。
Development of ciprofloxacin resistance due to chromosomal mutations induced by 2-nitrofluorene.
作者信息
Birosová Lucia, Mikulásová Mária
机构信息
Department of Biochemistry and Microbiology, Slovak University of Technology, Bratislava, Slovakia.
出版信息
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2005 Dec;149(2):401-3.
PMID:16601798
Abstract
In this paper we investigated the ability of 2-nitrofluorene to induce mutations leading to antibiotic resistance in quinolone-sensitive strain Salmonella typhimurium. After preincubation of bacteria with 2-nitrofluorene, the frequency of mutation to ciprofloxacin resistance was 57 fold higher than in the case of spontaneous mutability. Some of resultant resistant colonies showed a great increase of ciprofloxacin MIC.
摘要
在本文中，我们研究了2-硝基芴诱导喹诺酮敏感菌株鼠伤寒沙门氏菌产生导致抗生素抗性的突变的能力。在用2-硝基芴对细菌进行预孵育后，对环丙沙星抗性的突变频率比自发突变情况高57倍。一些产生的抗性菌落显示环丙沙星的最低抑菌浓度大幅增加。
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