发现用于神经酰胺从内质网到高尔基体运输的分子机制CERT。
Discovery of the molecular machinery CERT for endoplasmic reticulum-to-Golgi trafficking of ceramide.
作者信息
Hanada Kentaro
机构信息
Department of Biochemistry and Cell Biology, National Institute of Infectious Diseases, 1-23-1, Toyama, Tokyo 162-8640, Japan.
出版信息
Mol Cell Biochem. 2006 Jun;286(1-2):23-31. doi: 10.1007/s11010-005-9044-z.
Synthesis and sorting of lipids are essential events for membrane biogenesis and its homeostasis. Ceramide is synthesised at the endoplasmic reticulum (ER), and translocated to the Golgi compartment for conversion to sphingomyelin (SM). We have recently identified a key factor (named CERT) for ceramide trafficking. In this short review, I summarise recent advances in molecular mechanisms of intracellular transport of ceramide, focusing on our genetic and biochemical approaches to this issue.
脂质的合成与分选是膜生物发生及其稳态的重要过程。神经酰胺在内质网（ER）中合成，然后转运至高尔基体区室转化为鞘磷脂（SM）。我们最近鉴定出了一种神经酰胺转运的关键因子（命名为CERT）。在这篇简短的综述中，我总结了神经酰胺细胞内运输分子机制的最新进展，重点介绍了我们针对此问题所采用的遗传学和生物化学方法。
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