Anghileri E, Toso V, Perini F
UOC di Neurologia, Ospedale S. Bortolo, ULSS 6, Vicenza, Italy.
Neurol Sci. 2006 Feb;26(6):456-9. doi: 10.1007/s10072-006-0533-y.
The pain of cluster headache attacks is severe, excruciating and selectively responsive to subcutaneous sumatriptan. Serious cardiovascular events attributed to sumatriptan are extremely rare and have most often been reported in patients at significant cardiovascular risk, or in overt cardiovascular disease. They also have occurred, however, in patients without evidence of cardiovascular disease. We describe a 42-year-old man with episodic cluster headache without history of coronary artery disease who was admitted to our coronary care unit for acute myocardial infarction after 3 h of subcutaneous injection of sumatriptan. During hospitalisation cluster headache attacks were successfully treated with e.v. indomethacin.
丛集性头痛发作时的疼痛剧烈、难以忍受，且对皮下注射舒马曲坦有选择性反应。归因于舒马曲坦的严重心血管事件极为罕见，大多报道于有重大心血管风险的患者或明显心血管疾病患者中。然而，此类事件也发生在无心血管疾病证据的患者身上。我们描述了一名42岁的男性，他患有发作性丛集性头痛，无冠状动脉疾病史，在皮下注射舒马曲坦3小时后因急性心肌梗死入住我们的冠心病监护病房。住院期间，静脉注射吲哚美辛成功治疗了丛集性头痛发作。
