来自法国国家艾滋病研究机构（ANRS）HIV-2队列的HIV-2感染患者中，GB病毒C感染与疾病进展之间无关联。

No association between GB virus C infection and disease progression in HIV-2-infected patients from the French ANRS HIV-2 cohort.

作者信息

Descamps Diane, Damond Florence, Bénard Antoine, Matheron Sophie, Campa Pauline, Taieb Audrey, Yahyaoui Réda, Chêne Geneviève, Brun-Vézinet Françoise

机构信息

Hôpital Bichat-Claude Bernard, Paris, France.

出版信息

AIDS. 2006 Apr 24;20(7):1076-9. doi: 10.1097/01.aids.0000222086.29164.6e.

DOI:10.1097/01.aids.0000222086.29164.6e

PMID:16603866

Abstract

Out of 183 HIV-2-infected patients tested in the ANRS CO8 HIV-2 cohort, 69 were exposed to GB virus C (GBV-C), yielding a prevalence of 38% (95% CI 30.7, 45.2). There was no significant difference between the CD4 cell count and HIV-2-RNA plasma viral load in patients exposed and not exposed to GBV-C. After adjusting for age and CD4 cell count, co-infection with GBV-C was not associated with clinical progression (hazard ratio 0.78; 95% CI 0.24-2.56, 16 clinical events).

摘要

在法国国家艾滋病研究机构（ANRS）CO8 HIV-2队列中接受检测的183例HIV-2感染患者中，69例曾接触庚型肝炎病毒C（GBV-C），感染率为38%（95%置信区间30.7, 45.2）。接触和未接触GBV-C的患者之间，其CD4细胞计数和HIV-2-RNA血浆病毒载量无显著差异。在对年龄和CD4细胞计数进行校正后，GBV-C合并感染与临床进展无关（风险比0.78；95%置信区间0.24 - 2.56，16例临床事件）。