视网膜动脉阻塞患者房水中的谷氨酸水平。
Glutamate levels in aqueous humor of patients with retinal artery occlusion.
作者信息
Wakabayashi Yoshihiro, Yagihashi Tomoyuki, Kezuka Jun, Muramatsu Daisuke, Usui Masahiko, Iwasaki Takuya
机构信息
Department of Ophthalmology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.
出版信息
Retina. 2006 Apr;26(4):432-6. doi: 10.1097/00006982-200604000-00009.
PURPOSE
We analyzed the levels of glutamate and other amino acids in aqueous humor of patients with retinal artery occlusion (RAO) to determine whether glutamate is associated with retinal ischemia in RAO.
METHODS
Aqueous humor samples were obtained from nine RAO patients by paracentesis performed as an emergent therapeutic intervention and from nine cataract patients without other ocular disease who served as controls. Aspartic acid, glutamate, taurine, and alanine concentrations were determined using high-performance liquid chromatography.
RESULTS
The glutamate level in aqueous humor of patients with RAO (4.46 +/- 1.62 micromol/L) was significantly higher than that in controls (2.98 +/- 1.12 micromol/L) (P < 0.05).
CONCLUSIONS
Elevated glutamate levels in aqueous humor may indicate diffusion of vitreous glutamate released from the damaged retina due to acute retinal ischemia in RAO. An increase in the extracellular glutamate level may play an important role in ischemic retinal damage in RAO.
目的
我们分析了视网膜动脉阻塞（RAO）患者房水中谷氨酸及其他氨基酸的水平，以确定谷氨酸是否与RAO中的视网膜缺血有关。
方法
通过紧急治疗性穿刺从9例RAO患者获取房水样本，并从9例无其他眼部疾病的白内障患者（作为对照）获取房水样本。使用高效液相色谱法测定天冬氨酸、谷氨酸、牛磺酸和丙氨酸的浓度。
结果
RAO患者房水中的谷氨酸水平（4.46±1.62微摩尔/升）显著高于对照组（2.98±1.12微摩尔/升）（P<0.05）。
结论
房水中谷氨酸水平升高可能表明由于RAO中的急性视网膜缺血，受损视网膜释放的玻璃体谷氨酸发生了扩散。细胞外谷氨酸水平的升高可能在RAO的缺血性视网膜损伤中起重要作用。
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