牛晶状体囊基底膜胶原蛋白对多形核中性粒细胞产生负向启动作用。
Bovine lens capsule basement membrane collagen exerts a negative priming on polymorphonuclear neutrophils.
作者信息
Monboisse J C, Bellon G, Perreau C, Garnotel R, Borel J P
机构信息
Laboratoire de Biochimie, URA CNRS 610, Faculté de Médecine de l'Université de Reims, France.
出版信息
FEBS Lett. 1991 Dec 2;294(1-2):129-32. doi: 10.1016/0014-5793(91)81358-f.
After a 30 min contact between purified bovine lens capsule basement membrane type IV collagen and polymorphonuclear neutrophils, stimulation of these cells by N-formyl-methionyl-leucyl-phenylalanine, PMA or type I collagen releases a decreased amount of superoxide ions (negative priming). The inhibitory activity is located in the NCl domain. On the other hand, after pepsin digestion, the helical part of type IV collagen determines a positive priming of neutrophils.
纯化的牛晶状体囊基底膜IV型胶原与多形核中性粒细胞接触30分钟后，用N-甲酰甲硫氨酰亮氨酰苯丙氨酸、佛波醇肉豆蔻酸酯或I型胶原刺激这些细胞，超氧离子释放量减少（负启动）。抑制活性位于NCl结构域。另一方面，经胃蛋白酶消化后，IV型胶原的螺旋部分可引起中性粒细胞的正启动。
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