Yi Jae Youn, Han Innoc, Oh Eok-Soo
Laboratory of Tissue Engineering, Korea Institute of Radiological and Medical Sciences, Korea Atomic Energy Research Institute, Seoul 139-706, Korea.
ScientificWorldJournal. 2006 Apr 6;6:457-9. doi: 10.1100/tsw.2006.92.
Cell surface adhesion receptors of the syndecan family initiate intracellular events through clustering of receptors. This crucial clustering occurs through receptor dimerization or oligomerization, which is mediated by receptor transmembrane domains. However, the exact role of the transmembrane domain during receptor activation is not fully understood. Researchers have not yet determined whether the transmembrane domain functions solely in the physical aspects of receptor clustering, or whether the domain has additional functional roles. Here we review recent advances in understanding the functionality of transmembrane domain-dependent oligomerization of syndecan cell adhesion receptor.
Syndecan家族的细胞表面粘附受体通过受体聚集引发细胞内事件。这种关键的聚集通过受体二聚化或寡聚化发生，其由受体跨膜结构域介导。然而，跨膜结构域在受体激活过程中的确切作用尚未完全明确。研究人员尚未确定跨膜结构域是仅在受体聚集的物理方面发挥作用，还是该结构域具有其他功能作用。在此，我们综述了在理解Syndecan细胞粘附受体跨膜结构域依赖性寡聚化功能方面的最新进展。
